Подходы к нефармакологической модуляции нервной и иммунной коммуникации: терапевтический потенциал вибрационной стимуляции
- Авторы: Широлапов И.В.1, Павлова О.Н.1, Гуленко О.Н.1, Москвитина П.М.1
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Учреждения:
- Самарский государственный медицинский университет
- Выпуск: Том 106, № 3 (2025)
- Страницы: 422-431
- Тип: Обзоры
- URL: https://bakhtiniada.ru/kazanmedj/article/view/311411
- DOI: https://doi.org/10.17816/KMJ653398
- EDN: https://elibrary.ru/BONJXJ
- ID: 311411
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Аннотация
В настоящее время наряду с традиционной физической нагрузкой в целях клинической реабилитации или для достижения спортивных показателей применяются принципы активации нейромышечной системы с использованием рефлекторной интенсивной стимуляции, опосредованной вибрационным воздействием. В ряде исследований вибрационная физическая нагрузка как немедикаментозный метод воздействия на различные функциональные системы организма продемонстрировала свою эффективность в реабилитации двигательных расстройств и мышечной слабости, в коррекции гормональных и метаболических нарушений, остеопороза, кардиореспираторной и возраст-ассоциированной патологии. Иммунная дисфункция и возрастные изменения тесно коррелируют с процессами нейровоспаления и нейродегенерации. Последние данные указывают на положительное влияние вибрационного тренинга на иммунный ответ и высшие интегративные функции мозга, а также демонстрируют терапевтические возможности при заболеваниях нервной системы. В настоящей статье анализируется влияние вибрационной стимуляции нейромышечной системы на клеточные и молекулярные пути, вовлечённые в нейроиммунные коммуникации, и систематизированы имеющиеся данные о потенциале такого воздействия для немедикаментозной коррекции неврологических и иммунных нарушений. Анализ исходов различных программ вибрационной физической нагрузки подтверждает эффективность и многофункциональность данного вмешательства для коррекции соответствующего дефицита и позволяет рассматривать его как многообещающее дополнение к традиционным упражнениям и методам физической реабилитации. Однако вопросы о конкретных механизмах, посредством которых интенсивная проприоцептивная стимуляция в условиях вибрационного тренинга может влиять на различные аспекты функционирования нервной системы и иммунный ответ, остаются открытыми. Поэтому изучение данной технологии с помощью разнообразных модельных организмов и у человека, а также комплексное исследование результатов воздействия и всесторонняя оценка терапевтической эффективности будут способствовать более глубокому и системному пониманию особенностей её влияния на здоровье человека в целом.
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Игорь Викторович Широлапов
Самарский государственный медицинский университет
Автор, ответственный за переписку.
Email: ishirolapov@mail.ru
ORCID iD: 0000-0002-7670-6566
SPIN-код: 3939-3590
Scopus Author ID: 35776847200
кандидат медицинских наук, доцент, заведующий, лаб. Трансляционных исследований и персонализированной медицины НИИ нейронаук, доцент, каф. физиологии
Россия, 443079, Самара, ул. Гагарина, д. 18Ольга Николаевна Павлова
Самарский государственный медицинский университет
Email: o.n.pavlova@samsmu.ru
ORCID iD: 0000-0002-8055-1958
SPIN-код: 6326-6884
доктор биологических наук, доцент, заведующий, каф. физиологии
Россия, СамараОльга Николаевна Гуленко
Самарский государственный медицинский университет
Email: o.n.gulenko@samsmu.ru
ORCID iD: 0000-0001-6338-7095
SPIN-код: 6795-5163
кандидат биологических наук, доцент, каф. физиологии
Россия, 443079, Самара, ул. Гагарина, д. 18Полина Михайловна Москвитина
Самарский государственный медицинский университет
Email: p.m.moskvitina@samsmu.ru
ORCID iD: 0000-0002-0666-7442
SPIN-код: 5788-5795
ассистент, каф. физиологии
Россия, 443079, Самара, ул. Гагарина, д. 18Список литературы
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