The dynamics of liver tests in pregnant women with non-infectious hepatitis in the case of prescription of ademetionine
- Authors: Garayeva KG1
-
Affiliations:
- Scientific Research Institute of Obstetrics and Gynecology
- Issue: Vol 101, No 2 (2020)
- Pages: 296-303
- Section: Clinical experiences
- URL: https://bakhtiniada.ru/kazanmedj/article/view/26279
- DOI: https://doi.org/10.17816/KMJ2020-296
- ID: 26279
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Abstract
Aim. To study the effect of ademetionine on the dynamics of biochemical markers of liver disease in pregnant women with non-infectious hepatitis.
Methods. The study included 19 pregnant with non-infectious hepatitis (5 — alcoholic, 7 — drug, 7 — alimentary) etiologies. For groups comparison it was used the history of previous pregnancies in these same women. To monitor the functional state of the liver in the blood of women, the content of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and total bilirubin was determined using HUMAN reagent kits on a BIOSKREM MS 2000 microanalyzer (USA). Examination of pregnant women was carried out immediately after registration, at the end of the first and second trimesters of pregnancy.
Results. In pregnant women with a high content of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and total bilirubin in the blood, cases of pathological development of the fetus were recorded more often. The use of drugs based on ademetionine contributed to the positive dynamics of liver tests in drug and alimentary (caused by nutrition) hepatitis; no evidence of the positive dynamics in alcoholic hepatitis was obtained.
Conclusion. Prescribing of ademetionine to pregnant women with liver damage by non-infectious etiology can positively affect both the biochemical parameters of the liver and, possibly, the formation of the fetus.
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##article.viewOnOriginalSite##About the authors
K G Garayeva
Scientific Research Institute of Obstetrics and Gynecology
Author for correspondence.
Email: rjafarova@bk.ru
Azerbaijan, Baku, Azerbaijan
References
- Orudzhev R.A., Dzhafarova R.E. Changes in the nervous system state and peripheral blood parameters under benzene intoxication during an experiment. Analiz riska zdorov'yu. 2017; (4): 108–116. (In Russ.) doi: 10.21668/health.risk/2017.4.12.eng.
- Yudina N.V., Egorova E.Yu., Filosofova M.S. et al. A randomized controlled clinical and economic trial of the use of progepar in patients with chronic alcoholic hepatitis. Kachestvennaya klinicheskaya praktika. 2011; (1): 72–84. (In Russ.)
- Polukhova Sh.M., Musaeva E.M., Dzhafarova R.E. et al. Drug-induced hepatopathies. Vestnik Vitebskogo gosudarstvennogo meditsinskogo universiteta. 2018; 17 (4): 29–36. (In Russ.) doi: 10.22263/2312-4156.2018.4.29.
- Musayeva E.M., Guseynova G.A., Dzhafarova R.E. et al. Possibilities of pharmacological correction of pathologies of gepatobiliarny system. Vestnik Rossiyskoy voyenno-meditsinskoy akademii. 2018; (2): 221–225. (In Russ.)
- Baud F., Garnier R. Toxicologie Clinique. 6ème édition. Paris: Lavoisier. 2017; 1654 p.
- Zobnin Yu.V. Toxic injury of the liver in children. Sibirskiy meditsinskiy zhurnal (Irkutsk). 2017; (4): 37–53. (In Russ.)
- Buatois S., Le Merdy M., Labat L. et al. Principales modifications pharmacocinétiques chez l’enfant. Toxicol. Analytique & Clinique. 2014; (3): 156–164. doi: 10.1016/j.toxac.2014.06.003.
- Eremina E.Yu. Drug-induced hepatitis in pregnant women. Problemy zhenskogo zdorov'ya. 2011; 6 (4): 46–55. (In Russ.)
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