Synthesis, properties and biological activity of bis(diphenylphosphinylacetyl)hydrazine and its complex with iron (III)

R. I. Tavasova; Тарасова Р. И.; V. V. Moskva; Москва В. В.; O. V. Voskresenskaya; Воскресенская О. В.; A. V. Litvinenko; Литвиненко А. В.; I. I. Semina; Семина И. И.; A. Z. Baichurina; Байчурина А. З.; G. F. Rzhevskaya; Ржевская Г. Ф.

doi:10.17816/kazmj100627

Synthesis, properties and biological activity of bis(diphenylphosphinylacetyl)hydrazine and its complex with iron (III)

Authors: Tavasova R.I.¹^,2, Moskva V.V.¹^,2, Voskresenskaya O.V.¹^,2, Litvinenko A.V.¹^,2, Semina I.I.¹^,2, Baichurina A.Z.¹^,2, Rzhevskaya G.F.¹^,2
Affiliations:
1. Kazan Technological University
2. Kazan Medical University
Issue: Vol 76, No 3 (1995)
Pages: 193-196
Section: Pharmacy
URL: https://bakhtiniada.ru/kazanmedj/article/view/100627
DOI: https://doi.org/10.17816/kazmj100627
ID: 100627

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Abstract

The synthesis of bis (diphcnulphosphinylacetyl)hydrazine and its complex with iron (III) chloride is performed, their ultraviolet and infrared spectrums are investigated, the method of titrimetric determination of iron in the complex is developed. The initial ligand offers tranquilizing, antidepressive activity and does not affect the lenth of ethanol anesthesia of rats, and its complex with iron (III) chloride potentiates the lenth of ethanol anesthesia more than 3 times, however, does not manifest tranquilizing and antidepressive activity. Both of the products are low toxic compounds.

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