Role of genes involved in the regulation of apoptosis in the pathogenesis of genital endometriosis. A literature review

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BACKGROUND: The high prevalence, the lack of reliable data on the etiology, as well as the complexity of diagnosis and treatment of genital endometriosis indicate the urgency of the problem.

AIM: The aim of this study was to analyze and summarize scientific publications devoted to the study of single-nucleotide polymorphisms involved in apoptosis and their association with endometriosis.

MATERIALS AND METHODS: Based on keyword searches for “gene,” “SNP,” “apoptosis,” and “endometriosis,” a selection of papers published in open sources (PubMed and Google Scholar) in the period from 2010 to 2020 was performed.

RESULTS AND CONCLUSIONS: An analysis of the main and auxiliary apoptotic pathways was performed, with the protein regulators and their genes detailed in accordance with the implementation of the programmed cell death cascade in genital endometriosis. The review identified the significance of a number of proteins (TNF-á, FADD, CASP3, CASP7, CASP10) in the pathogenesis of hyperproliferative diseases. However, many apoptotic regulators (BCL2, BIK, BMF, HRK, BAD, Survivin) in genital endometriosis were found to have been understudied, which makes future research in this direction promising.

作者简介

Nelly Andreyeva

Ott Research Institute of Obstetrics, Gynecology and Reproductology

Email: nelly8352@yahoo.com
ORCID iD: 0000-0002-1928-1266
SPIN 代码: 3355-2646

MD, Junior Researcher 

俄罗斯联邦, 3, Mendeleevskaya line, Saint Petersburg, 199034

Maria Yarmolinskaya

Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott, Saint; North-Western State Medical University named after I.I. Mechnikov

Email: m.yarmolinskaya@gmail.com
ORCID iD: 0000-0002-6551-4147
SPIN 代码: 3686-3605
Scopus 作者 ID: 7801562649
Researcher ID: P-2183-2014

MD, Dr. Sci. (Med.), Professor, Professor of the Russian Academy of Sciences

俄罗斯联邦, 3, Mendeleevskaya line, Saint Petersburg, 199034; 41 Kirochnaya Str., Saint Petersburg, 191015

Tatiana Ivashchenko

Ott Research Institute of Obstetrics, Gynecology and Reproductology

编辑信件的主要联系方式.
Email: tivashchenko2011@mail.ru
ORCID iD: 0000-0002-8549-6505
Scopus 作者 ID: 7004724202

Dr. Sci. (Biol.), Professor, Leading Researcher of the Laboratory of Prenatal Diagnostics of congenial and Hereditary Diseases

俄罗斯联邦, 3, Mendeleevskaya line, Saint Petersburg, 199034

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2. Diagram of the external and internal pathways of apoptosis. Adapted from G. Ichim et al. A fate worse than death: apoptosis as an oncogenic process, 2016 [80]

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