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Post a Comment A prognostic efficiency of short-term tests - systems at an estimation of cancerogenic activity of chemical compounds
- Authors: Abilev S.K1, Tarasov A.V1, Tarasov V.A1
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Affiliations:
- N.I. Vavilov Institute of General Genetics RAS, Moscow, RF
- Issue: Vol 2, No 4 (2004)
- Pages: 12-21
- Section: Articles
- URL: https://bakhtiniada.ru/ecolgenet/article/view/5522
- DOI: https://doi.org/10.17816/ecogen2412-21
- ID: 5522
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Abstract
The method of an estimation prognostic efficiency of the battery of short-term tests at an estimation of potential cancerogenic activity of chemicals is offered. Levels of validity of cancerogenic activity 83 chemical compounds is carried out results at their testing in battery tests - test Ames, the test for SCE in cells in vitro, and the MNT - test in vivo. Researched date base is used as the trainee for forecasting potential cancerogenic activity of new chemical compounds by a method of cross-check
About the authors
Serikbay K Abilev
N.I. Vavilov Institute of General Genetics RAS, Moscow, RF
Email: serikbai@mail.ru
Aleksey V Tarasov
N.I. Vavilov Institute of General Genetics RAS, Moscow, RF
Valentin A Tarasov
N.I. Vavilov Institute of General Genetics RAS, Moscow, RF
Email: vat.vigg@mail.ru
References
- McCann J., Choi Ј., Yamasaki E., Ames B.N. Detection of carcinogens as mutagens in the Salmonella/microsome test:Assay of 300 chemicals//Proc. Natl. Acad. Sci. (USA). -1975. -Vol. 72. -P. 5135-5139.
- Chankong V., Haimes Y.Y., Rosenkranz H.S., Pet-Edwards J. The carcinogenicity prediction and battery selection (CPBS) method: a Bayesian approach//Mutation Res. -1985. -Vol. 153.-P. 135-166.
- Pet-Edwards J., Chankong V., Haimes Y.Y., Rosenkranz H.S. Application of the carcinogenicity prediction and battery selection (CPBS) method to theGene-Tox date base//Mutation Res. -1985. -Vol. 153. -P. 187-200.
- Heinze J.E., Poulson N.K. The optimal design of batteries of short-term tests for detecting carcinogens//Mutation Res. -1983. -Vol. 117. -P. 259-269.
- Lave L.D., Omenn G.S., Heffernan K.D., Dranoff G. A model for selecting short-term tests of carcinogenicity//J.Am. Coll. Toxocol. -1983, -Vol. 2. -P. 125-130.
- Lave L.D., Omenn CS. Cost-effectivness of short-term tests for carcinogenicity//Nature (London). -1986. -Vol. 324. -P. 29-34.
- Benigni R., Giuliani A. Which rules for assembling short-term test batteries to predict carcinogenicity?//Molec.Toxicol. -1987.-Vol. l. -P. 143-166.
- Тарасов В.А. Принципы качественной и количественной оценки генетической опасности химических веществ/Докл. Междунар. симп. Мутагены и канцерогены окружающей среды и наследственность человека//М.: 1994. -С. 3-66.
- Тарасов В.А., Асланян М.М., Абилев С.К Принципы формализованной количественной оценки опасности химических соединений для человека//Генетика. -1999. -Т. 35. -С. 1585-1599.
- Тарасов В.А., Тарасов А.В., Любимова И.К., Асланян М.М. Проблема количественной оценки опасности химических соединений в генетической токсикологии//Усп. соврем, биол. -2002. -Т. 122, №2. -С. 136-147.
- Тарасов В.А., Велибеков P.M., Любимова И.К., Асланян М.М. Низкая эффективность краткосрочных тестов при оценке потенциальной мутагенной опасности химических соединений//Генетика.-2001. -Т. 37, №7, -С. 1008-1017
- Тарасов В.А., Абилев С.К.,. Велибеков P.M., Асланян М.М. Эффективность батарей тестов при оценке потенциальной мутагенной опасности химических соединений//Генетика. -2003. -Т. 39, №10, -С. 1406-1417.
- Кастлер К. Азбука теории информации/В кн.: Теория информации в биологии//М.: Иностр. литература. -1960. -С. 9-53.
- Wiener N. Cybernetics, or control and communication in the animal and the machine//N.Y.: J. Wiley and Sons. Inc. -1948.
- Shannon C.E. A mathematical theory of communication//Bell Syst. Techn. J. -1948. -Vol. 27. -P. 379-423.
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