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Post a Comment Effect of the anticancer drug methotrexate on the ascites form of a teratocarcinoma and survival of mice
- Authors: Dyban P.A.1
-
Affiliations:
- Institute of Experimental Medicine
- Issue: Vol 16, No 3 (2018)
- Pages: 32-35
- Section: Articles
- URL: https://bakhtiniada.ru/RCF/article/view/10381
- DOI: https://doi.org/10.17816/RCF16332-35
- ID: 10381
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Abstract
The dose-dependent effect of a methotrexate is established as on an ascite form of a teratocarcinoma CBA9H6, and mice-recipients, however various doses of the entered methotrexate (6; 4 and 2 mkg/g body weights of an animal), at repeated introduction at an interval of 48 and 24 hours, don't destroy all population of embrioid bodies. So, at 3-fold and even 10-fold daily injections in a dose of 2 mkg/g of body weight in an abdominal cavity of mice 1,6 ± 0,2% and 0,038 ± 0,01% embrioid bodies (ascite form of a teratocarcinoma ) remain, respectively, at survival of mice 93,0 ± 8,5% and 14,0 ± 3,0%. The morphological analysis of a mode of a differentiation of embrioid bodies retransplantated from experimental animals to intact has shown earlier that the methotrexate hasn't had effect on histoblastic potentialities of stem cells of a teratocarcinoma CBA9H6.
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##article.viewOnOriginalSite##About the authors
Pavel A. Dyban
Institute of Experimental Medicine
Author for correspondence.
Email: pavandy@mail.ru
Dr. Med. Sci., Associate Professor, Leading Researcher, Department of Mol. Genetics
Russian Federation, St. PetersburgReferences
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