Polymorphisms of xenobiotic biotransformation genes and their role in individualization of pharmacological therapy and support of humans after heavy psychophysical loading


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Abstract

We analyzed the frequency distribution of CYP1A1, EPHX1, GSTM1, GSTP1, GSTT1 genes polymorphisms in 111 persons exposed to high physical and mental stress (elite athletes). Qualifications of sportsmen ranged from candidates for master of sports to world-class athlete. Comparative analysis revealed significant differences between the main group and the comparison group in the frequency of GSTM1, GSTT1, CYP1A1 genotypes, and a tendency to a predominance of genotype GSTP1 Val / Val in the main group.

About the authors

Anna Sergeevna Kozlova

Respublic Scientific and Practical Centre of Sport

Email: annete.kozlova@gmail.com
Master of Sci., Head, Laboratory of Pharmacology and Sport Nutrition

Alexandre Olegovich Pyatibrat

A. M. Nikiforov All-Russian Centre of Extreme and Radiation Med., Emercom of Russia

Email: a5brat@yandex.ru
PhD (Pathophysiology), Head of Dept. of Organization and Sc. Activity

Sergei Borisovich Melnov

A. D. Sakharov International State Ecological University

Email: sbmelnov@gmail.com
Dr. Biol. Sci. (Genetics), Professor, Head. Dept. of Environmental and Molecular Medicine

Nadezhda Sergeevna Smolnik

A. D. Sakharov International State Ecological University

Petr Dmitriyevich Shabanov

S. M. Kirov Military Medical Academy

Email: pdshabanov@mail.ru
Professor, Head, Dept. of Pharmacology

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Copyright (c) 2015 Kozlova A.S., Pyatibrat A.O., Melnov S.B., Smolnik N.S., Shabanov P.D.

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