Evaluation of the anti-inflammatory activity of melatonin in a model of experimental arthritis

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Abstract

The epiphyseal hormone melatonin (1 and 5 mg/kg) significantly limited locomotor and psychoemotional disorders, indicators of inflammation and immunological reactivity in rats with experimental adjuvant arthritis.

About the authors

Stanislav Sergeevich Naumov

Stavropol State Medical University

Author for correspondence.
Email: n_stanislav@mail.ru
SPIN-code: 4283-5843

Cand. Sci. (Med.)

Russian Federation, 310 Mira str., Stavropol, 355017

References

  1. Arushanyan EB. Limitation of oxidative stress as the main factor of the universal protective properties of melatonin. Experimental and Clinical Pharmacology. 2012;75(5):44–49. (In Russ.)
  2. Arushanyan EB, Naumov SS. Anti-inflammatory potential of melatonin. Klinicheskaya meditsina. 2013;91(7):18–22. (In Russ.)
  3. Carrillo-Vico A, Lardone PJ, Alvarez-Sánchez N, et al. Melatonin: buffering the immune system. Int J Mol Sci. 2013;14(4):8638–8683. doi: 10.3390/ijms14048638
  4. Hardeland R. Melatonin and inflammation – Story of a double-edged blade. J Pineal Res. 2018;65(4): e12525. doi: 10.1111/jpi.12525

Copyright (c) 2021 Naumov S.S.

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