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Post a Comment Effect of the extract of dry Serratula centauroides on the behavior of white rats in tests with positive reinforcement
- Authors: Razuvaeva Y.G.1,2, Markova K.V.3, Toropova A.A.1,2, Olennikov D.N.1
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Affiliations:
- Institute of General and Experimental Biology SB RAS
- Banzarov Buryat State University Republic of Buryatia
- Banzarov Buryat state University
- Issue: Vol 19, No 2 (2021)
- Pages: 237-242
- Section: Phytopharmacology
- URL: https://bakhtiniada.ru/RCF/article/view/57179
- DOI: https://doi.org/10.17816/RCF192237-242
- ID: 57179
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Abstract
The effect was studied of dry leaf extract of Serratula centauroides L. on the behavior of white rats (Wistar) in tests with positive reinforcement. It was revealed that the extract of S. centauroides at doses of 50–200 mg/kg promotes in animals a decrease in the level of anxiety, adaptation to unfamiliar conditions, and as a consequence, to an increase in the volume of food intake. And also a more rapid formation of a conditioned reflex with positive reinforcement. In animals treated with S. centauroides extract, the volume of food taken in “hypophagia” test was 1.4–2.7 times higher than the control value. In the T-shaped maze, 50–80% of the animals in the experimental groups developed a conditioned reflex to positive reinforcement, while none of the animals in the control group reached the learning criterion. The S. centauroides extract showed the most pronounced effect on the behavior of animals in tests with positive reinforcement at a dose of 100 mg/kg.
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##article.viewOnOriginalSite##About the authors
Yanina G. Razuvaeva
Institute of General and Experimental Biology SB RAS; Banzarov Buryat State University Republic of Buryatia
Author for correspondence.
Email: tatur75@mail.ru
ORCID iD: 0000-0001-7829-1424
SPIN-code: 8338-9336
DSci. (Biology), Senior Research Scientist, laboratory for the safety of biologically active substances
Russian Federation, 8 str. Sakhyanovoy, Ulan-Ude 670047; 24а str. Smolina, Ulan-Ude 670000Kristina V. Markova
Banzarov Buryat state University
Email: kriskartland@gmail.com
ORCID iD: 0000-0002-2143-6925
SPIN-code: 5739-5350
Postgraduate student
Russian Federation, 24а str. Smolina, Ulan-Ude 670000Anyuta A. Toropova
Institute of General and Experimental Biology SB RAS; Banzarov Buryat State University Republic of Buryatia
Email: anyuta-tor@mail.ru
ORCID iD: 0000-0003-2618-7777
SPIN-code: 4457-1872
Ph.D. (Biology), Research Scientist, laboratory for the safety of biologically active substances
Russian Federation, 8 str. Sakhyanovoy, Ulan-Ude 670047; 24а str. Smolina, Ulan-Ude 670000Daniil N. Olennikov
Institute of General and Experimental Biology SB RAS
Email: olennikovdn@mail.ru
ORCID iD: 0000-0001-8194-1061
SPIN-code: 8901-3743
DSci. (Pharm.), Senior Research Scientist, laboratory of biomedical research
Russian Federation, 8 str. Sakhyanovoy, Ulan-Ude 670047References
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