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Post a Comment Experimental study of neuropsychotropic activity
- Authors: Krasnova A.I.1, Pulina N.A.1, Polezhaeva V.D.1
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Affiliations:
- Perm State Pharmaceutical Academy
- Issue: Vol 40, No 3 (2023)
- Pages: 139-145
- Section: Biology and experimental medicine
- URL: https://bakhtiniada.ru/PMJ/article/view/254873
- DOI: https://doi.org/10.17816/pmj403139-145
- ID: 254873
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Abstract
Objective. To study the neuropsychotropic activity of 2,4-dioxobutanoic acid derivatives containing a fragment of benzimidazole as well as to determine the relationship between the structure of substances and their biological effects.
Materials and methods. The spectrum of neuropsychotropic activity of 2,4-dioxobutanoic acid derivatives with benzimidazole was studied on experimental animals using the «open field», «black-and-white camera», and «extrapolation deliverance» tests.
Results. A compound with potential anxiolytic properties has been identified. The dependence of the manifestation of anxiogenic or anxiolytic properties in the presence of mono- or bicyclic arenes in the structure, respectively, is shown.
Conclusions. 2,4-Dioxobutane acids containing a fragment of benzimidazole are of interest for the search for substances with neuropsychotropic activity. The results of the “structure-activity” analysis should be used in further targeted synthesis.
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##article.viewOnOriginalSite##About the authors
Anastasiya I. Krasnova
Perm State Pharmaceutical Academy
Author for correspondence.
Email: krasnova_ai@mail.ru
ORCID iD: 0000-0002-5363-8783
SPIN-code: 3520-1728
Scopus Author ID: 56430747900
Candidate of Pharmaceutical Sciences, Associate Professor, Department of Pharmacology
Russian Federation, PermNataliya A. Pulina
Perm State Pharmaceutical Academy
Email: pulina-nata@mail.ru
ORCID iD: 0000-0002-0435-0484
SPIN-code: 3972-0441
Scopus Author ID: 7801572754
Doctor of Pharmaceutical Sciences, Professor, Head of the Department of Pharmaceutical Technology
Russian Federation, PermValeriya D. Polezhaeva
Perm State Pharmaceutical Academy
Email: polezgaevalera@inbox.ru
postgraduate student, Assistant of the Department of Pharmaceutical Technology
Russian Federation, PermReferences
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