LEPTIN, PROINFLAMMATORY CYTOKINES AND FUNCTIONAL HEPATIC TESTS IN METABOLIC SYNDROME ASSOCIATED WITH FATTY HEPATIC LESION

Aim. To study the correlation between leptin, proinflammatory cytokines - tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), functional hepatic tests, lipid and carbohydrate metabolism indices in patients with metabolic syndrome (MS) associated with fatty lesion of the liver. Materials and methods. 50 patients with MS and fatty hepatic lesion and 30 practically healthy subjects were examined. Blood serum leptin, TNF-α and IL-6 concentrations were assessed with immunofermental analysis method. Glucose level, functional hepatic tests, lipid metabolism indices were studied. Hepatic sonography or computer tomography were carried out. Results. In patients with MS and fatty hepatic lesion, significant increase in blood serum leptin, TNF-α and IL-6 concentrations as compared to the group of practically healthy persons was detected. Reliable correlation between leptin, body mass index, atherogenic lipids and alkaline phospatase was stated. IL-6 concentration correlated with TNF-α and alkaline phosphatase. Maximum number of reliable correlations was revealed between TNF-α and the studied tests including transaminases, gamma-glutamiltranspeptidase, glucose, triglycerides, leptin. Cytolysis and cholestasis tests correlated with hyperlipidemia markers. Conclusion. Correlation between proinflammatory cytokines and cytolysis and cholestasis markers proves severity of hepatic lesion in MS patients. TNF-α most informatively reflects pathogenetic connection of disturbed carbohydrate and lipid metabolism with inflammatory response against the background of fatty lesion of the liver in case of metabolic syndrome.

Leptin, tumor necrosis factor-α, interleukin-6, metabolic syndrome