Correlation between dental symptoms and functional and clinical manifestations of Crohn's disease and ulcerative colitis
- Authors: Yunusova R.D.1,2, Usmanova I.N.1, Lakman I.A.1,3, Ishmukhametova A.N.1, Akopyan A.P.1, Gaisina E.A.4
-
Affiliations:
- Bashkir State Medical University
- Premier Dental Clinic
- Ufa University of Science and Technology
- Republican Clinical Hospital named after G.G. Kuvatov
- Issue: Vol 41, No 4 (2024)
- Pages: 5-15
- Section: Original studies
- URL: https://bakhtiniada.ru/PMJ/article/view/267865
- DOI: https://doi.org/10.17816/pmj4145-15
- ID: 267865
Cite item
Full Text
Abstract
Objective. To analyze the correlation between dental symptoms and clinical and functional manifestations of Crohn's disease (CD) and ulcerative colitis (UC).
Materials and methods. A prospective, observational, longitudinal clinical study of 70 patients with verified inflammatory bowel diseases, i.e. Crohn's disease and ulcerative colitis, has been performed. For an in-depth assessment of the oral mucosa (OM) and red lip border (RLB) condition in patients with these systemic diseases, a complete dental examination has been carried out. The validated questionnaire "7´7" was used to objectify the symptoms of functional gastric dyspepsia.
Results. In patients with the main clinical manifestations of the gastrointestinal tract impairments in CD and UC, extraintestinal dental manifestations in the form of meteorological cheilitis (16 and 9, respectively;
p = 0.081), glossitis (15 and 11, respectively; p = 0.323), onset of recurrent aphthous stomatitis (17 and 11;
p = 0.144), chronic mechanical trauma of oral mucosa (14 and 11; p = 0.455), and the presence of scalloped tongue (28 and 21, p = 0.068) were diagnosed. At the same time, the incidence of associated pathologies of OM and RLB was significantly higher in patients with CD (p<0.05) than in patients with UC. Clinical examination of patients revealed predominance of flatulence symptoms in patients with CD and UC in 74.3 and 77.1 % of cases, respectively (р = 0.771). Patients with CD prevailed in the number of dyspeptic disorders and their variability but statistically significant differences were determined only for the symptom 'abdominal pain decreasing after bowel emptying'. The correlation between the frequency of dyspeptic disorders in patients and characteristic changes in the clinical state of RLB and OM was revealed. For the CD and UC groups Chuprov conjugacy coefficients were statistically significant (ChC=0.36, ChC=0.28 respectively). In patients with CD clinically apparent changes in the RLB and OM associated with various dyspeptic disorders were manifested more often than in patients with UC.
Conclusion. The conducted study has shown that in patients with CD and UC there is a correlation between the frequency and severity of the main functional and clinical symptoms/syndromes (in the form of edema, hyperemia, pitting edema of the ОМ (in fact) and the RLB) and dyspeptic disorders, this correlation being stronger in Crohn's disease (p = 0.031 vs p = 0.046).
Full Text
##article.viewOnOriginalSite##About the authors
R. D. Yunusova
Bashkir State Medical University; Premier Dental Clinic
Email: irinausma@mail.ru
ORCID iD: 0000-0003-4556-0864
Postgraduate Student of the Department of Therapeutic Dentistry, Dental Therapist
Russian Federation, Ufa; UfaI. N. Usmanova
Bashkir State Medical University
Email: irinausma@mail.ru
ORCID iD: 0000-0002-1781-0291
DSc (Medicine), Associate Professor, Professor of the Department of Therapeutic Dentistry
Russian Federation, UfaI. A. Lakman
Bashkir State Medical University; Ufa University of Science and Technology
Email: irinausma@mail.ru
ORCID iD: 0000-0001-9876-9202
PhD (Technical Sciences), Leading Researcher of the Central Scientific Research Laboratory, Head of the Scientific Laboratory for the Research of Social and Economic Problems of the Regions
Russian Federation, Ufa; UfaA. N. Ishmukhametova
Bashkir State Medical University
Email: irinausma@mail.ru
ORCID iD: 0000-0003-0892-0058
PhD (Medicine), Associate Professor, Associate Professor of the Department of Internal Medicine and Clinical Psychology
Russian Federation, UfaA. P. Akopyan
Bashkir State Medical University
Email: irinausma@mail.ru
ORCID iD: 0000-0001-8436-5610
PhD (Medicine), Associate Professor of the Department of Neurology and Neurorehabilitation
Russian Federation, UfaE. A. Gaisina
Republican Clinical Hospital named after G.G. Kuvatov
Author for correspondence.
Email: irinausma@mail.ru
Chief Freelance Specialist in Gastroenterology, Head of the Gastroenterological Department, Gastroenterologist
Russian Federation, UfaReferences
- Torres J., Halfvarson J., Rodríguez-Lago I., Hedin C.R.H., Jess T., Dubinsky M., Croitoru K., Colombel J.-F. Results of the seventh scientific workshop of ECCO: Precision medicine in ibd-prediction and prevention of inflammatory bowel disease. J. Crohn’s Colitis. 2021; 15: 1443–1454. doi: 10.1093/ecco-jcc/jjab048.
- Jordi S.B.U., Lang B.M., Auschra B., von Känel R., Biedermann L., Greuter T., Schreiner P., Rogler G., Krupka N., Sulz M.C., Misselwitz B., Begré S., Swiss I.B.D. Cohort Study Group. Depressive Symptoms Predict Clinical Recurrence of Inflammatory Bowel Disease. Inflamm Bowel Dis. 2022; 28 (4): 560–571. doi: 10.1093/ibd/izab136.
- Jairath V., Feagan B.G. Global burden of inflammatory bowel disease. Lancet Gastroenterol Hepatol. 2020; 5 (1): 2–3. doi: 10.1016/S2468-1253(19)30358-9.
- Maertens A., Persyn D., Van Moerkercke W. How dyspepsia led to the diagnosis of Morbus Crohn. Acta Clin Belg. 2020; 75 (4): 293–295. doi: 10.1080/17843286.2019.1590497.
- Sinopoulou V., Gordon M., Akobeng A.K., Gasparetto M., Sammaan M., Vasiliou J., Dovey T.M. Interventions for the management of abdominal pain in Crohn's disease and inflammatory bowel disease. Cochrane Database Syst Rev. 2021; 11 (11): CD013531. doi: 10.1002/14651858.CD013531.pub2.
- Goldinova A., Tan C.X., Bouma G., Duijvestein M., Brand H.S., de Boer N.K. Oral health and salivary function in ulcerative colitis patients. United European Gastroenterol J. 2020; 8 (9): 1067–1075. doi: 10.1177/2050640620957138.
- Шелыгин Ю.А., Ивашкин В.Т., АчкАсов С.И. и др. Клинические рекомендации. Болезнь Крона (К50), взрослые. Колопроктология 2023; 22 (3): 10–49. doi: 10.33878/2073-7556-2023-22-3-10-49 / Shelygin Yu.A., Ivashkin V.T., Achkasov S.I. i dr. Clinical guidelines. Crohn’s disease (К50), adults. Koloproktologia 2023; 22 (3): 10–49. doi: 10.33878/2073-7556-2023-22-3-10-49 (in Russian).
- Шелыгин Ю.А., Ивашкин В.Т., Белоусова Е.А. и др. Язвенный колит (К51), взрослые. Колопроктология 2023; 22 (1): 10–44. doi: 10.33878/2073-7556-2023-22-1-10-44 / Shelygin Yu.A., Ivashkin V.T., Belousova E.A. I dr. Ulcerative colitis (K51), adults. Koloproktologia 2023; 22 (1): 10–44. doi: 10.33878/2073-7556-2023-22-1-10-44 (in Russian).
- Ивашкин В.Т., Шептулин А.А., Полуэктова Е.А., Рейхарт Д.В., Белостоцкий А.В., Дроздова А.А., Арнаутов В.С. Возможности применения Опросника «77» (7 симптомов за 7 дней) для оценки динамики симптомов функциональной диспепсии и синдрома раздраженного кишечника. Российский журнал гастроэнтерологии, гепатологии, колопроктологии. 2016; 26: 3: 24–33 / Ivashkin V.T., Sheptulin A.A., Poluektova Ye.A., Reykhart D.V., Belostotsky A.V., Drozdova A.A., Arnautov V.S. Potential of «77» (7 symptoms per 7 days) questionnaire in assessment of symptom dynamics of functional dyspepsia and irritable bowel syndrome. Russian journal of gastroenterology, hepatology, and coloproctology 2016; 26: 3: 24–33 (in Russian).
- Kochar B., Martin C.F., Kappelman M.D., Spiegel B.M., Chen W., Sandler R.S., Long M.D. Evaluation of Gastroin-testinal Patient Reported Outcomes Measurement Information System (GI-PROMIS) Symptom Scales in Subjects With Inflammatory Bowel Diseases. Am J Gastroenterol. 2018; 113 (1): 72–79. doi: 10.1038/ajg.2017.240
- Sahin T., Brygo A., Delaporte E., Ferri J. The oral effects of Crohn’s disease: De-scription of nine cases. Swiss dental journal SSO – Science and Clinical Topics. 2017; 127 (7/8): 649–653. doi: 10.61872/sdj-2017-07-08-05
- Kumar K.M., Nachiammai N., Madhushankari G.S. Association of oral manifestations in ulcerative colitis: A pilot study. J. Oral Maxillofac Pathol. 2018; 22 (2): 199–203. doi: 10.4103/jomfp.JOMFP_223_16.
- Гаус О.В., Ахмедов В.А., Коршунов А.С. Афтозный стоматит как дебют болезни Крона. Экспериментальная и клиническая гастроэнтерология 2019; (9): 97–100. doi: 10.31146/1682-8658-ecg-169-9-97-100 / Gaus O.V., Akhmedov V.A., Korshunov A.S. Aphthous stomati-tis as the debut of Crohn’s disease. Ex-perimental and Clinical Gastroenterolo-gy 2019; (9): 97–100. doi: 10.31146/1682-8658-ecg-169-9-97-100 (in Russian).
Supplementary files
