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Post a Comment Dynamics of main markers of protein metabolism and microelements in patients with new coronavirus infection
- Authors: Nikolenko V.V.1, Prelous I.N.1, Belkina E.V.1, Nikolenko P.A.1, Vorobyova N.N.1, Sumlivaya O.N.1, Nebolsina A.P.1, Bubnov A.M.1, Teterin V.Y.1
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Affiliations:
- E.A. Vagner Perm State Medical University
- Issue: Vol 41, No 1 (2024)
- Pages: 42-49
- Section: Original studies
- URL: https://bakhtiniada.ru/PMJ/article/view/254843
- DOI: https://doi.org/10.17816/pmj41142-49
- ID: 254843
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Abstract
Objective. To study the dynamics of the main markers of protein metabolism and microelements in patients with a new coronavirus infection.
Materials and methods. A prospective clinical and laboratory study of the dynamics of the main markers of protein metabolism and microelements was carried out in 62 patients with a new coronavirus infection complicated by the development of pneumonia with a moderate course on the basis of Perm regional clinical hospital of infectious diseases in 2021–2022. On the 1st and 14th days of hospitalization all patients underwent general clinical and biochemical studies. The concentrations of total protein, albumin, transferrin, Fe, Zn and Cu was also determined. Statistic processing of the results was carried out using Microsoft Excel 2000 and “Statistica 10”.
Results. A decrease in visceral pool proteins was revealed. It indicated their active consumption and formation of hypermetabolism - hypercatabolism syndrome in a moderate course of the infection. A progressive deficiency of Fe and Zn, correlating with life-threatening complications and deaths was revealed.
Conclusions. The course of a new coronavirus infection contributes to the development of metabolic disorders, and the identified deficiency of macro- and microelements is a predictor of a severe course of the infection.
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##article.viewOnOriginalSite##About the authors
V. V. Nikolenko
E.A. Vagner Perm State Medical University
Author for correspondence.
Email: vvn73@yandex.ru
ORCID iD: 0000-0002-9505-1569
MD, PhD, Professor of the Department of Infectious Diseases
Russian Federation, PermI. N. Prelous
E.A. Vagner Perm State Medical University
Email: pin197676@mail.ru
ORCID iD: 0000-0003-4194-5783
Candidate of Medical Sciences, Associate Professor of the Department of Anesthesiology, Resuscitation and Emergency Medical Aid
Russian Federation, PermE. V. Belkina
E.A. Vagner Perm State Medical University
Email: infect-perm@mail.ru
ORCID iD: 0009-0007-6822-398X
Assistant of the Department of Infectious Diseases
Russian Federation, PermP. A. Nikolenko
E.A. Vagner Perm State Medical University
Email: infect-perm@mail.ru
ORCID iD: 0009-0007-3067-5550
Resident of the Department of Oncology, Radiodiagnosis and Radiotherapy with Course of Radiology
Russian Federation, PermN. N. Vorobyova
E.A. Vagner Perm State Medical University
Email: infect-perm@mail.ru
ORCID iD: 0000-0001-5384-5910
MD, PhD, Professor, Head of the Department of Infectious Diseases
Russian Federation, PermO. N. Sumlivaya
E.A. Vagner Perm State Medical University
Email: vvn73@yandex.ru
ORCID iD: 0000-0003-0498-4900
MD, PhD, Professor of the Department of Infectious Diseases
Russian Federation, PermA. P. Nebolsina
E.A. Vagner Perm State Medical University
Email: infect-perm@mail.ru
ORCID iD: 0009-0006-3683-4367
Candidate of Medical Sciences, Assistant of the Department of Infectious Diseases
Russian Federation, PermA. M. Bubnov
E.A. Vagner Perm State Medical University
Email: vvn73@yandex.ru
ORCID iD: 0009-0006-7596-0948
Assistant of the Department of Anesthesiology, Resuscitation and Emergency Medical Aid
Russian Federation, PermV. Yu. Teterin
E.A. Vagner Perm State Medical University
Email: vvn73@yandex.ru
ORCID iD: 0009-0007-2162-8111
Candidate of Medical Sciences, Associate Professor of the Department of Infectious Diseases
Russian Federation, PermReferences
- Луфт В.М., Афончиков В.С., Дмитриев А.В., Ерпулева Е.В., Лапицкий А.В., Лекманов А.У., Луфт А.В., Назаров В.И., Попова Т.С., Расновская Н.Ф., Сергеева А.М., Тропская Н.С., Трофимов П.А., Шестопалов А.Е. Руководство по клиническому питанию. 3-е изд. М.: Арт-Экспресс. 2016; 492. / Luft V.M., Afonchikov V.S., Dmitriev A.V., Erpuleva E.V., Lapitsky A.V., Lekmanov A.U., Luft A.V., Nazarov V.I., Popova T.S., Rasnovskaya N.F., Sergeeva A.M., Tropskaya N.S., Trofimov P.A., Shestopalov A.E. Guide to Clinical Nutrition. 3rd ed. Mocsow: Art-Express 2016; 492 (in Russian).
- Николенко В.В., Николенко А.В., Миникеева М.Р. Изучение изменений нутритивного статуса у ВИЧ – позитивных пациентов с пневмониями, вызванными Streptococcus рneumoniaе. Пермский медицинский журнал. 2018; 4: 14–19. / Nikolenko V.V., Nikolenko A.V., Minikeyeva M.R. Study of changes in nutritional status in HIV-positive patients with pneumonia caused by Streptococcus pneumoniae. Perm Medical Journal 2018; 4:14–19 (in Russian).
- Хубутия М.Ш., Поповой Т.С., Салтанова А.И. Парентеральное и энтеральное питание: национальное руководство. М.: ГЭОТАР-Медиа, 2014. / Khubutia M.Sh., Popova T.S., Saltanova A.I. Parenteral and enteral nutrition: National guidelines. Mocsow: GEOTAR-Media 2014 (in Russian).
- Velthuis A., Sjoerd H.E., Sims A. Zn2+ inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture. PLoS Pathogens. 2010; 6.
- Киселев С.В., Белова Е.В. Проблемы продовольственной безопасности и питания в России в современных условиях. Научные исследования экономического факультета. 2020; 1 (12): 70–91. / Kiselev S.V., Belova E.V. Problems of food security and nutrition in Russia in modern conditions. Scientific research of the Faculty of Economics 2020; 1 (12): 70–91 (in Russian).
- Мингазова Э.Н., Гуреев С.А. Значение микронутриентного статуса различных социальных групп населения при инфекционных рисках. Бюллетень Национального научно-исследовательского института общественного здоровья имени Н.А. Семашко. 2020; 3: 20–27. / Mingazova E.N., Gureev S.A. The significance of the micronutrient status of various social groups of the population in relation to infectious risks. Bulletin of the National Research Institute of Public Health named after N.A. Semashko 2020; 3: 20–27 (in Russian).
- Гречко А.В., Евдокимов Е.А., Котенко О.Н., Крылов К.Ю., Крюков Е.В., Луфт В.М., Никитюк Д.Б., Петриков С.С., Петрова М.В., Погожева А.В., Попова Т.С., Проценко Д.Н., Рык А.А., Свиридов С.В., Стародубова А.В., Стец В.В., Тармаева И.Ю., Тутельян В.А., Шарафетдинов Х.Х., Шестопалов А.Е., Яковлева А.В. Нутритивная поддержка пациентов с коронавирусной инфекцией COVID-19 А.В. Клиническое питание и метаболизм 2020; 1 (2): 56–91. / Grechko A.V., Evdokimov E.A., Kotenko O.N., Krylov K.Yu., Kryukov E.V., Luft V.M., Nikityuk D.B., Petrikov S.S., Petrova M.V., Pogozheva A.V., Popova T.S., Protsenko D.N., Ryk A.A., Sviridov S.V., Starodubova A.V., Stets V.V., Tarmaeva I Yu., Tutelyan V.A., Sharafetdinov Kh. Kh., Shestopalov A.E., Yakovleva A.V. Nutritional support for patients with coronavirus infection COVID-19 A.V. Clinical nutrition and metabolism 2020; 1 (2): 56–91 (in Russian).
- Николенко В.В., Белкина Е.В., Прелоус И.Н., Якушева М.В., Зернина М.Г., Голикова Е.В. Изменения нутритивного статуса у вакцинированных и не вакцинированных пациентов с коронавирусной инфекцией COVID-19. Инфекционные болезни в современном мире: эволюция, текущие и будущие угрозы: сборник трудов XIV Ежегодного всероссийского конгресса по инфекционным болезням имени академика В.И. Покровского М. 2022; 122–123. / Nikolenko V.V., Belkina E.V., Prelous I.N., Yakusheva M.V., Zernina M.G., Golikova E.V. Changes in nutritional status in vaccinated and unvaccinated patients with COVID-19 coronavirus infection. In the book: Infectious diseases in the modern world: evolution, current and future threats. Collection of proceedings of the XIV Annual All-Russian Congress on Infectious Diseases named after Academician V.I. Pokrovsky. Mocsow 2022; 122–123 (in Russian).
- Николенко В.В., Прелоус И.Н., Белкина Е.В., Воробьева Н.Н., Неболсина А.П. Изменения нутритивного статуса у пациентов с новой коронавирусной инфекцией. Забайкальский медицинский вестник 2022; 4:146–154. / Nikolenko V.V., Prelous I.N., Belkina E.V., Vorobyova N.N., Nebolsina A.P. Changes in nutritional status in patients with new coronavirus infection. Transbaikal Medical Bulletin 2022; 4: 146–154 (in Russian).
- Пасечник И.Н. Нутритивная поддержка больных коронавирусной инфекцией в критических состояниях. Анестезиология и реаниматология. 2020; 3: 70–75. / Pasechnik I.N. Nutritional support for patients with coronavirus infection in critical conditions. Anesthesiology and resuscitation 2020; 3: 70–75 (in Russian).
- Николенко А.В, Лейдерман И.Н., Николенко В.В. Скрининг ключевых маркеров обмена белка и микронутриентов у пациентов отделений реанимации и интенсивной терапии с острой патологией органов брюшной полости. Вестник интенсивной терапии имени А.И. Салтанова 2019; 4: 81–87. /Nikolenko A.V., Leiderman I.N., Nikolenko V.V. Screening of key markers of protein and micronutrient metabolism in intensive care unit patients with acute pathology of the abdominal organs. Bulletin of Intensive Care named after A.I. Saltanova 2019; 4: 81–87 (in Russian).
- Лейдерман И.Н., Ярошецкий А.И. К вопросу о потребности в белке пациентов отделений реанимации и интенсивной терапии. Вестник интенсивной терапии имени А.И. Салтанова 2018; 3: 59–66. / Leiderman I.N., Yaroshetsky A.I. On the issue of protein needs of patients in intensive care units and intensive care units. Bulletin of Intensive Care named after A.I. Saltanova 2018; 3: 59–66 (in Russian).
- Goncalves T.J.M., Goncalves S.E.A.B., Guarnieri A. et al. Association between low zinc levels and severity of acute respiratory distress syndrome by new coronavirus SARS-CoV-2. Nutr. Clin. Pract. 2021; 1 (36): 186–191.
- Громова О.А., Торшин И.Ю. Важность цинка для поддержания активности белков врожденного противовирусного иммунитета: анализ публикаций, посвященных COVID-19. Профилактическая медицина 2020; 3 (23): 131–139. / Gromova O.A., Torshin I.Yu. The importance of zinc in maintaining the activity of innate antiviral immune proteins: analysis of publications on COVID-19. Preventive medicine 2020; 3 (23): 131–139 (in Russian).
- Skalny A.V., Timashev P.S., Aschner M. Serum zinc, copper, and other biometals are associated with COVID-19 severity markers. Metabolites. 2021; 4 (11): 244.
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