Email this article Prevalence of GJB2 gene mutation 35delG among healthy population of Northwest Region of Russia
- Authors: Zhuravskiy SC1, Ivanov SA2, Taraskina AE3, Grinchik OV4, Kurus AA1
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Affiliations:
- Pavlov State Medical University of the Federal Agency for Public Health and Social Development of the Russian Federation
- Medical Academy of Postgraduate Edication
- B. P. Konstantinov Petersburg Nuclear Physics Institute of the Russian Academy of Sciences
- Kaliningrad Regional Clinical Hospital
- Issue: Vol 9, No 2 (2009)
- Pages: 41-45
- Section: Articles
- URL: https://bakhtiniada.ru/MAJ/article/view/9349
- DOI: https://doi.org/10.17816/MAJ9241-45
- ID: 9349
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Abstract
Mutation 35delG of GJB2 gene is a major genetic factor of hereditary recessive prelingual deafness in Caucasian population. This study investigated heterozygous carrier prevalence of the mutation among healthy native population of Northwest region of Russia. DN A analysis was carried out on blood material from inhabitants (n=1153) of Arkhangelsk, Pskov, Saint Petersburg and Kaliningrad region. The prevalence of heterozygous 35delG/GJB2 mutation in healthy individuals was found to be 5.0%, 4.7%, 5.5%, and 7.5%, respectively, which is considerably higher than the average prevalence in Europe. Possible causes of such high prevalence of the 35delG/GJB2 mutation are discussed.
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##article.viewOnOriginalSite##About the authors
S C Zhuravskiy
Pavlov State Medical University of the Federal Agency for Public Health and Social Development of the Russian Federation197089, Санкт-Петербург, ул. Л.Толстого, д. 6/8
S A Ivanov
Medical Academy of Postgraduate Edication191015, Санкт-Петербург, ул. Кирочная, д. 41
A E Taraskina
B. P. Konstantinov Petersburg Nuclear Physics Institute of the Russian Academy of Sciences188300, Ленинградская область, г. Гатчина, Орлова роща
O V Grinchik
Kaliningrad Regional Clinical Hospital236016, Калининград, ул. Клиническая, д. 74
A A Kurus
Pavlov State Medical University of the Federal Agency for Public Health and Social Development of the Russian Federation197089, Санкт-Петербург, ул. Л.Толстого, д. 6/8
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