Effect of vitamin D3 (cholecalciferol) levels on the development of cognitive and psychoemotional disorders in patients with cerebrovascular disease
- Authors: Lobzin S.V.1, Shvartsman G.I.1, Pervova E.M.1, Chistova I.V.1, Yurkina E.A.1
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Affiliations:
- North-Western State Medical University named after I.I. Mechnikov
- Issue: Vol 20, No 1 (2020)
- Pages: 93-100
- Section: Clinical research
- URL: https://bakhtiniada.ru/MAJ/article/view/19225
- DOI: https://doi.org/10.17816/MAJ19225
- ID: 19225
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Abstract
In recent years, the problem of vascular cognitive impairment is becoming increasingly important due to the increasing prevalence of cerebrovascular disease. The aim of this study was to determine the relationship between 25(OH)D, highly sensitive CRP, interleukin-1β, interleukin-6 and cognitive function in patients with cerebrovascular disease and to assess their impact on quality of life.
Materials and methods. 58 patients with cerebrovascular disease aged 31–81 years were examined. The comparison group consisted of 24 patients, comparable in age and sex, without the studied pathology. In the study, patients were determined by the level of 25(OH)D, interleukin-1β, interleukin-6, highly sensitive CRP in peripheral blood. All patients underwent neuropsychological, psychometric examination and study of their quality of life.
Results. In the study, the level of 25(OH)D in patients with cerebrovascular disease was lower compared to the group without this pathology. Concentrations of interleukin-1β, interleukin-6, and highly sensitive CRP in patients in the main group were statistically significantly higher than in those in the comparison group. Higher concentrations of highly sensitive CRP, interleukin-1β, and interleukin-6 were found in patients with low vitamin D availability. The study obtained direct correlations between the level of 25(OH)D in peripheral blood and the results of neuropsychological testing (MMSE, MoCA, FAB, Schulte tables (performance), the “Drawing hours” test) and the inverse with the degree of workability (Schulte tables). An inverse correlation of average strength was observed between the results of psychometric testing and the level of 25(OH)D in peripheral blood. The study confirmed the relationship between the level of 25(OH)D in peripheral blood and quality of life indicators, in the form of a direct correlation.
Conclusion. The study found that the higher the concentration of 25 (OH)D and the lower the level of interleukin-1β, interleukin-6, and highly sensitive CRP in the peripheral blood, the less likely it is to develop cognitive and psychoemotional disorders. The study confirmed the relationship between the level of 25(OH)D and quality of life indicators.
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##article.viewOnOriginalSite##About the authors
Sergey V. Lobzin
North-Western State Medical University named after I.I. Mechnikov
Email: sergei.lobzin@szgmu.ru
SPIN-code: 7274-6327
Ph.D., Professor, Сhief of the Neurology Department named after S.N. Davidenkov, North-Western State Medical University named after I.I. Mechnikov
Russian Federation, 41, Kirochnaya street, Saint-Petersburg, 191015Grigoriy I. Shvartsman
North-Western State Medical University named after I.I. Mechnikov
Email: shvartsman@inbox.ru
SPIN-code: 9510-2049
PhD, professor, professor of the department of neurology named after academician S.N. Davidenkov
Russian Federation, 41, Kirochnaya street, Saint-Petersburg, 191015Evgenia M. Pervova
North-Western State Medical University named after I.I. Mechnikov
Author for correspondence.
Email: p01081981@yandex.ru
SPIN-code: 5163-8761
postgraduate student of the department of neurology named after academician S.N. Davidenkov
Russian Federation, 41, Kirochnaya street, Saint-Petersburg, 191015Inga V. Chistova
North-Western State Medical University named after I.I. Mechnikov
Email: ingachistova@yandex.ru
Candidate of Medical Sciences, Assistant of the of the Department of Neurology named after Academician S.N. Davidenkov
Russian Federation, 41, Kirochnaya street, Saint-Petersburg, 191015Ekaterina A. Yurkina
North-Western State Medical University named after I.I. Mechnikov
Email: eayurkina@mail.ru
SPIN-code: 9725-7246
Candidate of Medical Sciences, Assistant of the of the Department of Neurology named after Academician S.N. Davidenkov
Russian Federation, 41, Kirochnaya street, Saint-Petersburg, 191015References
- Гусев Е.И., Боголепова А.Н. Когнитивные нарушения при цереброваскулярных заболеваниях. – М.: МЕДпресс-информ, 2013. [Gusev EI, Bogolepova AN. Kognitivnye narusheniya pri tserebrovaskulyarnykh zabolevaniyakh. Moscow: MEDpress-inform, 2013. (In Russ.)]
- Яхно Н.Н., Боголепова А.Н., Захаров В.В. Нарушение когнитивных функций // Неврология: национальное руководство / под ред. Е.И. Гусева, А.Н. Коновалова, В.И. Скворцовой. – М.: ГЭОТАР-Медиа, 2018. – C. 244–257. [Yakhno NN, Bogolepova AN, Zakharov VV. Narushenie kognitivnykh funktsiy. In: Nevrologiya: natsional’noe rukovodstvo. Ed. by E.I. Gusev, A.N. Konovalov, V.I. Skvortsova. Moscow: GEOTAR-Media; 2018. P. 244-257 (In Russ.)]
- Annweiler C, Dursun E, Feron F, et al. Vitamin D and cognition in older adults‘: updated international recommendations. J Intern Med. 2015;277(1):45-57. https://doi.org/10.1111/joim.12279.
- Bartali B, Devore E, Grodstein F, Kang JH. Plasma vitamin D levels and cognitive function in aging women: the nurses’ health study. J Nutr Health Aging. 2014;18(4):400-406. https://doi.org/10.1007/s12603-013-0409-9.
- Снопов С.А. Механизмы действия витамина D на иммунную систему // Медицинская иммунология. – 2014. – Т. 16. – № 6. – C. 499–530. [Snopov SA. Mechanisms of vitamin D action on the immune system. Medical Immunology (Russia). 2014;16(6):499-530. (In Russ.)]. https://doi.org/10.15789/1563-0625-2014-6-499-530.
- McAfoose J, Baune BT. Evidence for a cytokine model of cognitive function. Neurosci Biobehav Rev. 2009;33(3):355-366. https://doi.org/10.1016/j.neubiorev.2008.10.005.
- Захарова Н.И., Тихомирова О.В., Дрыгина Л.Б., и др. Значение повышения уровня высокочувствительного С-реактивного белка и гомоцистеина в развитии сосудистых когнитивных нарушений у мужчин // Медико-биологические и социально-психологические проблемы безопасности в чрезвычайных ситуациях. – 2010. – Т. 4. – № 1. – С. 63–66. [Zakharova NI, Tikhomirova OV, Drygina LB, et al. Consquences of elevated high sensitive C-reactive protein and homocysteine to vascular cognitive impairment in middle-aged men. Medico-biological and socio-psychological problems of safety in emergency situations. 2010;4(1):63-66. (In Russ.)]
- Скворцова В.И., Стаховская Л.В., Гудкова В.В., Алехин А.В. Хроническая недостаточность мозгового кровообращения // Неврология: национальное руководство / под ред. Е.И. Гусева, А.Н. Коновалова, В.И. Скворцовой. – М.: ГЭОТАР-Медиа, 2018. – C. 338–349. [Skvortsova VI, Stakhovskaya LV, Gudkova VV, Alekhin AV. Khronicheskaya nedostatochnost’ mozgovogo krovoobrashcheniya. In: Nevrologiya: natsional’noe rukovodstvo. Ed. by E.I. Gusev, A.N. Konovalov, V.I. Skvortsova. Moscow: GEOTAR-Media; 2018. P. 338-349. (In Russ.)]
- Кадыков А.С., Манвелова Л.С. Тесты и шкалы в неврологии. – М.: МЕДпресс-информ, 2016. [Kadykov AS, Manvelova LS. Testy i shkaly v nevrologii. Moscow: MEDpress-inform; 2016. (In Russ.)].
- Захаров В.В., Вознесенская Т.Г. Нервно-психические нарушения: диагностические тесты. – М.: МЕДпресс-информ, 2018. [Zakharov VV, Voznesenskaya TG. Nervno-psikhicheskie narusheniya: diagnosticheskie testy. Moscow: MEDpress-inform; 2018. (In Russ.)]
- Пигарова Е.А., Рожинская Л.Я., Белая Ж.Е., и др. Клинические рекомендации Российской ассоциации эндокринологов по диагностике, лечению и профилактике дефицита витамина D у взрослых // Проблемы эндокринологии. – 2016. – № 4. – С. 60–84. [Pigarova EA, Rozhinskaya LY, Belaya ZhE, et al. Russian Association of Endocrinologists recommendations for diagnosis, treatment and prevention of vitamin D deficiency in adults. Problems of endocrinology. 2016;(4):60-84. (In Russ.)]. https://doi.org/10.21320/2500-2139-2017-10-3-294-316.
- Wang TJ, Pencina MJ, Booth SL, et al. Vitamin D deficiency and risk of cardiovascular disease. Circulation. 2008;117(4):503-511. https://doi.org/10.1161/CIRCULATIONAHA.107.706127.
- Шульгинова А.А., Конопля А.И., Быстрова Н.А., и др. Коррекция иммунных нарушений при хронической ишемии головного мозга // Медицинская иммунология. – 2018. – T. 20. – № 3. – С. 401–410. [Shul’ginova AA, Konoplya AI, Bystrova NA, et al. Correction of immune disturbances in chronic cerebral ischemia. Meditsinskaia immunologiia. 2018;20(3):401-410. (In Russ.)]. https://doi.org/10.15789/1563-0625-2018-3-401-410.
- Bruyere O, Slomian J, Beaudart C, et al. Prevalence of vitamin D inadequacy in European women aged over 80 years. Arch Gerontol Geriatr. 2014;59(1):78-82. https://doi.org/10.1016/j.archger.2014.03.010.
- Каронова Т.Л., Андреева А.Т., Беляева О.Д., и др. Тревожно-депрессивные расстройства у лиц с разным уровнем обеспеченности витамином D // Журнал неврологии и психиатрии им. С.С. Корсакова. – 2015. – T. 10. – № 2. – С. 55–58. [Karonova TL, Andreeva AT, Belyaeva OD, et al. Anxiety/depressive disorders and vitamin D status. Zh Nevrol Psikhiatr Im S S Korsakova. 2015;10(2):55-58. (In Russ.)]. https://doi.org/10.17116/jnevro201511510255-58.
- Барбараш О.Л., Лебедева Н.Б., Каретникова В.Н., и др. Провоспалительные факторы и депрессия при инфаркте миокарда // Кардиоваскулярная терапия и профилактика. – 2011. – T. 10. – № 2. – С. 53–59. [Barbarash OL, Lebedeva NB, Karetnikova VN, et al. Pro-inflammatory cytokines and depression in myocardial infarction. Cardiovascular therapy and prevention. 2011;10(2):53-59. (In Russ.)]. https://doi.org/10.15829/1728-8800-2011-2-53-59.
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