Молекулярные механизмы лекарственной устойчивости глиальных опухолей мозга. Часть 2. Пролиферация, ангиогенез, метастазирование и рецидивирование

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Аннотация

Главная причина низкой эффективности лечения глиобластомы — ее устойчивость к терапевтическим процедурам. Развитие множественной лекарственной устойчивости происходит в результате отбора опухолевых клонов во время терапии. Резистентные к радиотерапии или химиотерапии клоны клеток могут пролиферировать, приводя к росту опухоли, в которой образуется собственная сеть сосудов (ангиогенез), способствующая миграции и инвазии клеток, и, как следствие, появлению метастазов и рецидивов глиобластомы. В обзоре рассмотрена взаимосвязь на молекулярном уровне множественной лекарственной устойчивости с пролиферацией, ангиогенезом, миграцией, метастазированием и образованием рецидивов глиобластомы с акцентом на выявлении новых мишеней среди белков, микроРНК, киназ сигнальной трансдукции, транскрипционных факторов, генов-супрессоров и онкогенов.

Об авторах

Александр Николаевич Чернов

Институт экспериментальной медицины

Автор, ответственный за переписку.
Email: al.chernov@mail.ru
ORCID iD: 0000-0003-2464-7370

канд. биол. наук, научный сотрудник отдела общей патологии и патологической физиологии

Россия, Санкт-Петербург

Эльвира Сафуановна Галимова

Институт экспериментальной медицины; Институт эволюционной физиологии и биохимии им. И.М. Сеченова РАН

Email: elya-4@yandex.ru
ORCID iD: 0000-0002-8773-0932
Scopus Author ID: 24331659400

канд. биол. наук, старший научный сотрудник; старший научный сотрудник

Россия, Санкт-Петербург; Санкт-Петербург

Ольга Валерьевна Шамова

Институт экспериментальной медицины; Санкт-Петербургский государственный университет

Email: oshamova@yandex.ru
ORCID iD: 0000-0002-5168-2801
Scopus Author ID: 6603643804
ResearcherId: F-6743-2013

д-р биол. наук, доцент, член-корреспондент РАН, заведующий отделом общей патологии и патологической физиологии; профессор кафедры биохимии

Россия, Санкт-Петербург; Санкт-Петербург

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