Violations of the aerobic routes of energy synthesis: problems, consequences, possible approaches to their solution

The evolutionarily developed digestive system of humans and animals is now faced with a fundamentally changed diet. The processes of nutrient metabolism began to proceed with an excessively high synthesis of acidic energy metabolism products that are very problematic for the body. With a large accumulation, they become toxic to the body. In this regard, understanding the peculiarities of the conversion of nutrients into energy and the involvement of energy substrates in energy metabolism is the basis for studying the mechanism of development of pathobiochemical processes, including the search for means of purposeful activation of the involvement in energy metabolism of the most problematic energy substrates such as lactate, lipids, ketoacids. Attention is drawn to the well-known, little-known and unknown aspects of the transformation of nutrients into energy substrates. The ways of formation of problematic energy substrates for the body that cause disturbances are shown.

metabolism, energy metabolism, substrates, succinates, lactate, pyruvate, pathobiochemical processes, glycolysis, gluconeogenesis, lipolysis, Krebs cycle