GENOTYPES AND PHENOTYPES OF ALZHEIMER’S DISEASE


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Abstract

Aim - research of gene APOE for definition of allele structures of the human population phenotypes resulting in risk of Alzheimer’s disease. Materials and methods. Use of the Hardy-Weinberg theory and statistical researches of the alleles distribution of gene APOE in a human population. Results. Principles of the phenotype allele structures formation resulting in risk of Alzheimer’s disease are investigated. The expediency of these phenotypes finding is shown. On the basis of the received phenotypes distribution in human population the dependence of phenotype frequencies on risk of Alzheimer’s disease is investigated. The most dangerous phenotypes are revealed. Conclusion. On the basis of representation about dominant and recessive structure of gene APOE alleles it is shown that in a human population exists three phenotypes which determine the risk of Alzheimer’s disease. Distribution of these phenotypes in populations is investigated.

About the authors

AN N Volobuev

Samara State Medical University

Email: volobuev47@yandex.ru
PhD, Professor, Head of the Department of medical physics, mathematics and informatics of SamSMU.

VF F Pyatin

Samara State Medical University

Email: pyatin_vf@list.ru
PhD, Professor, Head of the Department of physiology with the course of life safety of vital activity and medicine of catastrophes of SamSMU.

NP P Romanchuk

Samara State Medical University

Email: romanchuknp@mail.ru
post-graduate of the Department of physiology with the course of life safety of vital activity and medicine of catastrophes of SamSMU.

NN N Aleksandrova

Samara State Medical University

Email: grecova71@mail.ru
senior lecturer of the Department of medical physics, mathematics and informatics of SamSMU.

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Copyright (c) 2018 Volobuev A.N., Pyatin V.F., Romanchuk N.P., Aleksandrova N.N.

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