Tumor models in the investigation of oral cancer pathogenesis and treatment development
- Авторлар: Tretyakova M.S.1, Prostakishina E.A.1, Kolegova E.S.1, Choinzonov E.L.1, Denisov E.V.1
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Мекемелер:
- Tomsk National Research Medical Center of the Russian Academy of Sciences
- Шығарылым: Том 29, № 4 (2025): MEDICAL GENETICS
- Беттер: 480-487
- Бөлім: CYTOLOGY
- URL: https://bakhtiniada.ru/2313-0245/article/view/359604
- DOI: https://doi.org/10.22363/2313-0245-2025-29-4-480-487
- EDN: https://elibrary.ru/AHVILO
- ID: 359604
Дәйексөз келтіру
Толық мәтін
Аннотация
Relevance. Oral cancer is one of the most common cancers among neoplasms of the head and neck. Oral cancer is characterized by a poor prognosis, a lack of specific biomarkers and highly effective targeted treatment. Experimental model systems are needed to study oral cancer pathogenesis and develop new treatments. Understanding the molecular features of oral cancer represents one of the key steps in developing new therapeutic strategies. A wide range of biological models is currently available, but their versatility is limited. Experimental models for studying oral cancer have evolved from cell cultures to in vivo systems that mimic pathological processes and the tumor-stroma interactions. Here, we summarized the available information on the current state of experimental oral cancer systems. In vitro models include immortalized and primary cell lines, spheroids and organoids, whereas in vivo models are represented by syngeneic and xenogeneic models, immunocompromised, immunocompetent, humanized, and genetically engineered animals. In vitro models are effective in studying the biology of oral tumors and evaluating the effectiveness of therapy due to high reproducibility and speed of obtaining results. Existing cell lines are widely used for fundamental and translational research and serve as a crucial component in preclinical trials. In vivo models are used in phase II of preclinical research in drug development and thus represent a transitional stage to clinical trials. Conclusion. Despite significant progress in the development of variousexperimental models, each of them has its own advantages and limitations. There is no universal model that allows for the complete extrapolation of the obtained results to the human body. Therefore, when planning research, it is crucial to select carefully the most suitable biological models based on the objectives at hand.
Негізгі сөздер
Авторлар туралы
Maria Tretyakova
Tomsk National Research Medical Center of the Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: trremar@mail.ru
ORCID iD: 0000-0002-5040-931X
SPIN-код: 5207-8330
Tomsk, Russian Federation
Elizaveta Prostakishina
Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: trremar@mail.ru
ORCID iD: 0000-0002-1405-3723
SPIN-код: 4517-4433
Tomsk, Russian Federation
Elena Kolegova
Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: trremar@mail.ru
ORCID iD: 0000-0001-9122-3274
SPIN-код: 5865-1264
Tomsk, Russian Federation
Evgeny Choinzonov
Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: trremar@mail.ru
ORCID iD: 0000-0002-3651-0665
SPIN-код: 2240-8730
Tomsk, Russian Federation
Evgeny Denisov
Tomsk National Research Medical Center of the Russian Academy of Sciences
Email: trremar@mail.ru
ORCID iD: 0000-0003-2923-9755
SPIN-код: 9498-5797
Tomsk, Russian Federation
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