Email this article The possible role of dopamine receptors DOP-1 and DOP-3 in behavior thermotolerance regulation of Caenorhabditis elegans Maupas
- Authors: Kalinnikova T.B.1, Kolsanova R.R.1, Belova E.B.1, Khakimova D.M.2, Gainutdinov M.K.1, Shagidullin R.R.1
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Affiliations:
- Research Institute for Problems of Ecology and Mineral Wealth Use of Tatarstan Academy of Sciences
- Kazan (Volga Region) Federal University
- Issue: Vol 7, No 2 (2018)
- Pages: 63-68
- Section: 03.02.00 – General Biology
- URL: https://bakhtiniada.ru/2309-4370/article/view/21722
- DOI: https://doi.org/10.17816/snv201872112
- ID: 21722
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Abstract
The paper investigates dopamine influence on the tolerance of swimming, induced by mechanical stimulus, to the temperature of 36°C during the experiments with nematodes of wild type strain N2 and mutant strains LX636 (dop-1(vs101)) and LX703 (dop-3(vs106)) with null-mutations of genes of dopamine receptors DOP-1 and DOP-3. The authors have shown that dopamine in concentrations 0,5–1,0 mM increased the behavior thermotolerance of C. elegans while in concentrations 7,5–15,0 dopamine caused its decrease. Null-mutation of dopamine receptor gene dop-3 prevented the decrease of C. elegans thermotolerance by dopamine. On the contrary, null-mutation of dopamine receptor gene dop-1 caused significant rise in sensitivity of behavior thermotolerance to dopamine. In connection with well-known conceptions assuming that the reason of heat damage of C. elegans behavior is acetylcholine deficiency due to inhibition of its secretion by hyperthermia, the dopamine influence on behavior thermotolerance can be accounted for the dopamine influence on acetylcholine secretion by motor neurons. It is known that in C. elegans motor neurons the coexpression of genes of receptors DOP-1 and DOP-3 takes place. Activation of these receptors in turn causes opposite changes in dopamine secretion.
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##article.viewOnOriginalSite##About the authors
Tatiana Borisovna Kalinnikova
Research Institute for Problems of Ecology and Mineral Wealth Use of Tatarstan Academy of Sciences
Email: tbkalinnikova@gmail.com
candidate of biological sciences, head of the Laboratory of Experimental Ecology
Russian Federation, KazanRufina Rifkatovna Kolsanova
Research Institute for Problems of Ecology and Mineral Wealth Use of Tatarstan Academy of Sciences
Email: rufina@kolsanova.com
candidate of biological sciences, researcher of the Laboratory of Experimental Ecology
Russian Federation, KazanEvgenia Borisovna Belova
Research Institute for Problems of Ecology and Mineral Wealth Use of Tatarstan Academy of Sciences
Email: dzhesi@yandex.ru
junior researcher of the Laboratory of Experimental Ecology
Russian Federation, KazanDilyara Makhmutrievna Khakimova
Kazan (Volga Region) Federal University
Email: diazkzn@mail.ru
candidate of medical sciences, senior lecturer of the Department of Morphology and General Pathology
Russian Federation, KazanMarat Khamitovich Gainutdinov
Research Institute for Problems of Ecology and Mineral Wealth Use of Tatarstan Academy of Sciences
Email: mgainutdinov@gmail.com
doctor of biological sciences, professor, senior researcher of the Laboratory of Experimental Ecology
Russian Federation, KazanRifgat Roaldovich Shagidullin
Research Institute for Problems of Ecology and Mineral Wealth Use of Tatarstan Academy of Sciences
Author for correspondence.
Email: shagidullin_@mail.ru
doctor of chemical sciences, corresponding member of the Tatarstan Academy of Sciences, director
Russian Federation, KazanReferences
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