Vol 2, No 6 (2014)
- Year: 2014
- Articles: 32
- URL: https://bakhtiniada.ru/2307-9266/issue/view/5609
Articles
PHENOLIC COMPOUNDS OF WATER-ETHANOLIC EXTRACT OF MENTHA LONGIFOLIA L
Abstract
The article represents data about qualitative and quantitative composition of phenolic compounds in water-ethanol extract of perspective clone of Mentha longifolia L. of NBE-NSC selection. Phenolic substances content in water-ethanol extract amounted to 3003.3 mg/100g. 13 components were determined in the extract. The extract contains caffeic acid, chlorogenic acid isomers, rosmarinic acid and glycosides of luteolin. Rosmarinic acid (50.2%) prevails among phenolic substances of Mentha longifolia extract. The conclusion is that the use of this extract is possible to create products with high biological value.
Pharmacy & Pharmacology. 2014;2(6):5-7
5-7
SEASONAL DYNAMICS OF WATER-SOLUBLE POLYSACCHARIDES CONTENT IN THE HERB OF HOARY ALYSSUM
Abstract
Seasonal dynamics of water-soluble polysaccharides (WSP) in the herb of Hoary alyssum has been studied. We have established that maximum content of WSP in plants accumulates during bloom and beginning of frutification. Seasonal dynamics of WSP content in the herb of Hoary alyssum was studied for the first time.
Pharmacy & Pharmacology. 2014;2(6):8-10
8-10
11-14
COMPONENT CONTENT OF ECHINOPS SUBGLABER SHRENK. AND ECHINOPS MEYERI (DC.) ILJIN
Abstract
The article presents the results of chemical content study of two species from Echinops L. genus which grow in Kazakhstan. Quinolinic alcloids echinopsine, echinopsidin and 4-quinolon, lupenon triterpenoid were identified in examined plants.
Pharmacy & Pharmacology. 2014;2(6):15-17
15-17
MORPHOLOGICAL AND ANATOMICAL STUDY OF THE FOOTSTALK AND OF THE BUDS OF CÓRNUS MAS L. OF CORNEL FAMILY (CORNACEAE DUMORT.)
Abstract
Decoctions of fruits, leaves, and also tendrils, roots and bark of the footstalk of the Сornus mas are used in traditional medicine. The purpose of this work is a study of morphological and anatomical signs of a footstalk and the buds of the Сornus mas for further development of standard documentation on medicinal raw materials. Morphological and аnatomical features of the footstalk and the buds of the plant were defined.
Pharmacy & Pharmacology. 2014;2(6):18-21
18-21
VOLATILE COMPOUNDS OF WATER-ETHANOLIC EXTRACT OF SATUREJA MONTANA L
Abstract
We have studied a composition and content of volatile compounds of Satureja montana L. extract. It was established that concentration of volatile compounds in water-ethanol extract of S. montana amounted to 325 mg/100g. The principal component of the extract is carvacrol. It was shown that the extract of Satureja montana represents high biological value.
Pharmacy & Pharmacology. 2014;2(6):22-24
22-24
COMPONENT COMPOSITION OF ESSENTIAL OIL FROM SPECIES OF GENUS NEPETA L
Abstract
Data about content and component composition of essential oil of six species from genus Nepeta L. in the condition of South coast of the Crimea have been given for the first time. We have identified from 16 to 21 components. Specimen with cytronellol content up to 58,42% and geranilacetat content up to 14,60% have been selected.
Pharmacy & Pharmacology. 2014;2(6):25-28
25-28
29-32
ANATOMICAL ORGANIZATION OF VEGETATIVE ORGANS OF ASTRAGALUS CICER L
Abstract
Astragalus cicer L . is a plurannual grassy plant of Fabaceae family which is widespread on the territory of central Russia and is used in folk medicine for treatment of different diseases. The article presents the results of anatomical organization of vegetative organs of Astragalus cicer L. The revealed features of anatomical organization of stem and leaf may be used for Astragalus cicer L. raw materials diagnosis.
Pharmacy & Pharmacology. 2014;2(6):33-35
33-35
36-38
PERSPECTIVE DRUG DOSAGE OF NEUTROPIC REMEDY ON THE BASIS OF EXCIPIENT FROM ROOTS OF PEGANUM HARMALA L
Abstract
This article represents the results of technological researches on development of new neurotropic remedy based on water-soluble excipient of harmine hydrochloride. Peroral remedy in capsules at dose of 30 mg which correspond to pharmaceutical quality indices have been developed for the first time.
Pharmacy & Pharmacology. 2014;2(6):39-41
39-41
OSMOLYTIC AND ADSORPTIVE ACTIVITIES DETERMINATION IN VITRO OF OINTMENT COMPONENTS ON THE BASIS OF CO2 EXTRACT FROM SEEDS OF SCHIZANDRA CHINENSIS
Abstract
There are data about positive effects from treatment of different skin diseases, sluggishly granulating wounds, and trophic ulcers with drugs based on Schizandra chinensis in literature sources. The purpose of this work is elaboration of soft external drug form - ointment on the basis of CO 2 extract of Schizandra chinensis seeds. Biopharmaceutical researches in vitro were carried out to choose optimal ointment composition with osmolytic and absorptive activity. Researches on osmolytic activity determination were conducted by the common method of equilibrium dialysis through semi-permeable membrane; adsorption activity of model ointment compositions was registered on their capability to sorb coloring agent. Thus we have established that all model ointment compositions under consideration have osmolytic (by the efficiency as well as by duration) and adsorptive activity and can be used at different stages of wound process.
Pharmacy & Pharmacology. 2014;2(6):42-47
42-47
PROSPECTS OF PRODUCTION AND USE OF BUTAMINOFEN SUPPOSITORY FOR ANOGENITAL HERPES TREATMENT
Abstract
The article shows theoretic substantiation of a butaminofen suppositories production reasonability - a new drug elaborated and synthesized in Belarus State University. We have considered the prospects of butaminofen suppositories use for anogenital herpes treatment. Evidence of a substance timeliness are based on the results of pharmacological, biopharmaceutical properties analysis of butaminofen and its marketing research.
Pharmacy & Pharmacology. 2014;2(6):48-50
48-50
51-53
METHODS ELABORATION ON DETECTION OF SOME ATYPICAL NEUROLYTIC AGENTS FOR CHEMICAL AND TOXICOLOGICAL ANALYSIS
Abstract
It is necessary to elaborate methods of atypical neuroleptic agents detection as individual substances and in different combinations as well for diagnosis of poisoning by some of them: clozapine, risperidone, sertindole, olanzapine, aripiprazole. The purpose of this work is methods elaboration of detection of clozapine, risperidone, sertindole, olanzapine, aripiprazole, haloperidol, oxazepam, carbamazapine using TLC, HPLC and UV spectrophotometry methods.During this work we used tablet forms of clozapine, risperidone, sertindole, olanzapine, aripiprazole. It is possible to use solution systems like ethanol-water-25% ammonia solution (8:1:1), toluol-acetone-ethanol-25% ammonia solution (45:45:7.5:2.5), dioxan-chloroform-acetone-25% ammonia solution (47.5:45:5:2.5) for preliminary examination of atypical neuroleptic agents under study in combination with typical neuroleptics and tranquilizers with undirected analysis (general screening). System of solvents ethyl-acetate-chloroform-25% ammonia solution (85:10:5) is recommended to use for individual screening of risperidone, sertindole, olanzapine, haloperidol, benzol-ethanol-25% ammonia solution (50:10:0.5) system to use for clozapine, sertindole, olanzapine. Ethanol-25% ammonia solution (100:1.5) system is reasonable to use for chromatographic clearance of extracts from biological substances under study. We recommend using HPLC method and UV spectrophotometry for carrying out of a principal examination of clozapine, risperidone, sertindole, olanzapine and aripiprazole in case one of the substances under study is determined in the object.
Pharmacy & Pharmacology. 2014;2(6):54-58
54-58
59-61
A NEW AYAFROL PHYTOPREPARATION BIOACCESSIBILITY STUDY
Abstract
The articles describes the results of "Ayafrol, 3% ointment" phytopreparation bioaccessibility study on the basis of essential oil of Ajania fruticulosa for local treatment of wounds. We have studied pharmacokinetics of the phytopreparation with estimation of intensity of essential oil components general action on organism after its penetration in systemic blood. The method is based on isolated liquid extraction of substances from serum of experimental animals. The results showed that there was no cumulation of phytopreparation components in system blood in 24 hours exposition while applying it locally. High concentration of a substance may occur directly on the wound surface. Thus Ayafrol ointment components are oriented on a local action towards wounds, directly in a place of contact of wound surface.
Pharmacy & Pharmacology. 2014;2(6):62-65
62-65
UROGENITAL CHLAMYDIOSIS: CURRENT STATE (REVIEW)
Abstract
Today, infectious diseases of urogenital tract are the reason of the whole range of pathological states. Despite the successes of scientific society in the development of contemporary methods for diagnosis and treatment of sexually transmissive infections their prevalence rate is still high. The review covers the most frequent bacterial sexually transmissive infection chlamydiosis, its prevalence rate and treatment methods.
Pharmacy & Pharmacology. 2014;2(6):66-73
66-73
INFLUENCE OF COLURIA GEOIDES (ROSACEAE) BAC ON HUMORAL IMMUNE RESPONCE
Abstract
The article presents the results of immunocorrecting properties of dry extract fractions of C. geoides (Rosaceae) for experimental immunodeficiency. Since the BAC fractions action relinquishes to the action of integral extract, the isolation of active substances is not reasonable.
Pharmacy & Pharmacology. 2014;2(6):74-76
74-76
COLURIA GEOIDES (ROSACEAE) BAC INFLUENCE ON CELLULAR IMMUNE RESPONSE
Abstract
The article presents the results of influence estimation of dry extract fractions of C. geoides (Rosaceae) at different stages of cell-mediated immune response in DHS reaction. Fraction of water-soluble BAC more actively stimulated the synthesis of pro-inflammatory cytokines at the stage of DHS solution.
Pharmacy & Pharmacology. 2014;2(6):77-79
77-79
EXPERIMENTAL APPROACHES TO IMMUNOPHARMACOTHERAPY FOR TOXIC HEPATITIS
Abstract
Humoral and cellular factors of natural resistance in different blood vessels for experimental CCl 4-hepatitis have been studied. Sharp decrease of all factors have been detected with prevailing suppression of cellular link in lever veins and gradual increase of lysozime by 14 days which supposes the use of corresponding immunoprotectors in post-desintoxication period.
Pharmacy & Pharmacology. 2014;2(6):80-83
80-83
SOME FEATURES OF CURATIVE ACTION OF A MILK THISTLE OIL REALIZATION FOR LEVER TOXICAL DAMAGE WITH FORMALINE
Abstract
The article represents the results of experimental researches of metabolic disorders provoked by subacute formalin injection to rats and study of possibility for correction of received changes by the saint milk thistle oil by the changes of clinical and biochemical indices of transaminases, creatinine, general protein, general cholesterol, glucose and triglycerides level in blood.
Pharmacy & Pharmacology. 2014;2(6):84-87
84-87
88-91
92-95
96-98
ANALGETIC ACTIVITY OF SUBSTITUTED 1-(2-IMIDAZOLETHYL)-3- PYRROLINE-2-ONS
Abstract
The article presents the review of initial stage of carried out studies of an analgetic activity of substituted 1-(2-imidazolethyl)-3-pyrroline-2-ons. We have established that compound marked with laboratory cipher as GKN-1165 at a dose of 50 mg/kg has analgetic activity close to the activity of ethanol of nimesulid comparison taken at the same dose.
Pharmacy & Pharmacology. 2014;2(6):99-101
99-101
EFFICIENCY OF METHOD OF SPONTANEOUS NOTIFICATION ABOUT UNDESIRABLE DRUG REACTIONS IN VOLGOGRAD
Abstract
Spontaneous notifications method is frequently the principal source of information about undesirable drug reactions (UDR). Volgograd regional center of drugs safety screening has been receiving about 182 notifications a year from doctors about UDR. The majority (34%) of the notifications were about UDR of antimicrobial drugs. UDR during treatment with cardio-vascular drugs amounted to 12% of all registered UDR in the region.
Pharmacy & Pharmacology. 2014;2(6):102-104
102-104
105-113
DEMAND ON ADSORPTIVE INTESTINAL PREPARATIONS ANALYSIS USING A VYSHKOVSKY'S INDEX
Abstract
The article presents the results of Vyshkovsky's index use for adsorptive intestinal preparations demand analysis. We have also considered a possibility of a new adsorption intestinal preparation launch on the Russian pharmaceutical market.
Pharmacy & Pharmacology. 2014;2(6):114-116
114-116
SPECIFIC MARKETING STUDIES OF ASSORTMENT OF DIURETIC DRUGS IN PYATIGORSK PHARMACIES
Abstract
Diuretics are ones of the most popular classes of antihypertensive remedies. They are characterized by low cost, high efficiency, and a good acceptability. Therefore the purpose of the research was to study an assortment of diuretics and to develop merchandise inventory of a pharmacy organization to improve quality of population drug supply. During the research we used methods of system, economic and statistic analysis, questioning, content-analysis and ABC-analysis. The research resulted on three groups of diuretic remedies depending on the specific density in general revenues from realization of these drugs group A. Group B amounted to 29.3% of the turnover. The rest 13 names were included in a Group C, their share was 29.4% of an amount of diuretics drugs. Pharmacy should always have drugs from the groups A and B.
Pharmacy & Pharmacology. 2014;2(6):117-121
117-121
REGINOAL PECULARITIES OF HYPOTENSIVE DRUGS USE BY PREGNANT WOMEN
Abstract
Hypotensive drugs applied by pregnant women in gestational and post-gravidary periods are limited by four basic groups of antihypertensive substances. Administration of other drugs is rare and do not have a tendency to grow. The majority of drugs corresponds to the following criteria: they are low cost, they are used during several decades. Beta-adrenergic blockers are the leaders among the hypotensive drugs for pregnant women. On the whole, pharmacotherapy of a high blood pressure of contingent under study corresponds to international recommendations.
Pharmacy & Pharmacology. 2014;2(6):122-124
122-124
TANTALIC RADIO-OPAQUE DRUGS. PRECLINICAL STUDIES" MONOGRAPHY REVIEW. Lambert Academic Publishing, 2012. 250 p
Pharmacy & Pharmacology. 2014;2(6):125-127
125-127