Identification of specific IgG class antibodies to certain flaviviruses in the population of the Republic of Guinea
- Authors: Krivosheina E.I.1, Kartashov M.Y.1, Naidenova E.V.2, Ushkalenko N.D.1, Svirin K.A.1, Bah M.B.3, Nourdine I.4, Boumbaly S.4, Ternovoi V.A.1
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Affiliations:
- State Research Center for Virology and Biotechnology “Vector”
- Russian Research Anti-Plague Institute “Microbe”
- Research Institute of Applied Biology of Guinea
- Hemorrhagic Fevers Virology Research Center
- Issue: Vol 14, No 2 (2024)
- Pages: 381-386
- Section: SHORT COMMUNICATIONS
- URL: https://bakhtiniada.ru/2220-7619/article/view/262379
- DOI: https://doi.org/10.15789/2220-7619-IOS-15081
- ID: 262379
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Abstract
One of the most common arboviruses in the world are representatives of the genus Orthoflavivirus (family Flaviviridae). On the territory of the Republic of Guinea, the circulation of such representatives of this family as the yellow fever virus (YFV), West Nile virus (WNV) and dengue virus (DENV) has been confirmed. The aim of the study was to determine the level of specific IgG class antibodies to YFV, DENV and WNV in residents of various landscape– geographical zones of the Republic of Guinea by the ELISA method. Materials and methods. For the study, a panel of 1559 blood serums from practically healthy people was compiled, which were collected in all landscape and geographical zones of the Republic of Guinea. The detection of specific IgG class antibodies to DENV and WNV was carried out with commercial diagnostic drugs, and for YFV — with an experimental ELISA test system based on an analogue of the third domain of protein E obtained at the State Research Center for Virology and Biotechnology “Vector” of Rospotrebnadzor. Results. When testing blood sera in 28.5% (95% CI: 26.3–30.7) of cases, IgG antibodies to YFV, to DENV — in 11.8%, (95% CI: 10.3–13.5) and to WNV — in 27.0% (95% CI: 24.8–29.3) were detected. Antibodies to three viruses simultaneously (YFV, DENV and WNV) were detected in 30 cases, to YFV and DENV — 14, YFV and WNV — 44, DENV and WNV — 56. Conclusion. The detection of antibodies to WNV and DENV confirms the fact of the continued circulation of these pathogens in the territory of the Republic of Guinea, which poses a health risk to the local population. A detailed study of the molecular genetic and antigenic properties of flaviviruses circulating in this area will allow the development of more specific diagnostic tools.
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##article.viewOnOriginalSite##About the authors
E. I. Krivosheina
State Research Center for Virology and Biotechnology “Vector”
Author for correspondence.
Email: katr962@mail.ru
Researcher, Department of Development and Production of Diagnostic Tools for Viral Diseases
Russian Federation, Koltsovo, Novosibirsk RegionM. Yu. Kartashov
State Research Center for Virology and Biotechnology “Vector”
Email: katr962@mail.ru
PhD (Biology), Senior Researcher, Department of Molecular Virology for Flaviviruses and Viral Hepatitis
Russian Federation, Koltsovo, Novosibirsk RegionE. V. Naidenova
Russian Research Anti-Plague Institute “Microbe”
Email: katr962@mail.ru
PhD (Biology), Leading Researcher, Department of Infectious Diseases Diagnostics
SaratovN. D. Ushkalenko
State Research Center for Virology and Biotechnology “Vector”
Email: katr962@mail.ru
Junior Researcher, Department of Development and Production of Diagnostic Tools for Viral Diseases
Russian Federation, Koltsovo, Novosibirsk RegionK. A. Svirin
State Research Center for Virology and Biotechnology “Vector”
Email: katr962@mail.ru
Junior Researcher, Department of Molecular Virology for Flaviviruses and Viral Hepatitis
Russian Federation, Koltsovo, Novosibirsk RegionM. B. Bah
Research Institute of Applied Biology of Guinea
Email: katr962@mail.ru
Researcher
Guinea, KindiaI. Nourdine
Hemorrhagic Fevers Virology Research Center
Email: katr962@mail.ru
PhD (Biology), Researcher
Guinea, ConakryS. Boumbaly
Hemorrhagic Fevers Virology Research Center
Email: katr962@mail.ru
PhD (Biology), Director of the Laboratory
Guinea, ConakryV. A. Ternovoi
State Research Center for Virology and Biotechnology “Vector”
Email: katr962@mail.ru
PhD (Biology), Acting Head of the Department of Molecular Virology for Flaviviruses and Viral Hepatitis
Russian Federation, Koltsovo, Novosibirsk RegionReferences
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