Email this article The Adaptation Role of Serine/Threonine Kinase Akt1 in Anabolism of Muscular Tissue
- Authors: Sukhorukov V.S.1,2, Baranich T.I.2, Atochin D.N.3,4, Glinkina V.V.2
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Affiliations:
- Center of Personalized Medicine, Sechenov First Moscow State Medical University
- Pirogov Russian National Research Medical University
- Russian-Speaking Academic Science Association (RASA) Center, National Research Tomsk Polytechnic University
- Cardiovascular Research Center, Cardiology Department, Massachusetts General Hospital, Harvard Medical School
- Issue: Vol 8, No 6 (2018)
- Pages: 489-496
- Section: Article
- URL: https://bakhtiniada.ru/2079-0864/article/view/206669
- DOI: https://doi.org/10.1134/S2079086418060105
- ID: 206669
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Abstract
The article reviews the particular qualities of the key signal component of anabolic pathways (serine/threonine kinase Akt1) in the regulation of skeletal muscle functioning, both under normal conditions and in the dystrophic process, including Duchenne’s muscular dystrophy. The current data confirm the participation of the Akt1 signal pathway in the processes of skeletal muscle regeneration, as well as in the mechanism of angiogenesis amplification, which demonstrates the great therapeutic potential of Akt1 as a target for the treatment of a wide range of hereditary and acquired neuromuscular diseases.
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About the authors
V. S. Sukhorukov
Center of Personalized Medicine, Sechenov First Moscow State Medical University; Pirogov Russian National Research Medical University
Author for correspondence.
Email: vsukhorukov@gmail.com
Russian Federation, Moscow; Moscow
T. I. Baranich
Pirogov Russian National Research Medical University
Author for correspondence.
Email: baranich_tatyana@mail.ru
Russian Federation, Moscow
D. N. Atochin
Russian-Speaking Academic Science Association (RASA) Center, National Research Tomsk Polytechnic University; Cardiovascular Research Center, Cardiology Department, Massachusetts General Hospital, Harvard Medical School
Author for correspondence.
Email: atochin@cvrc.mgh.harvard.edu
Russian Federation, Tomsk; Charlestown
V. V. Glinkina
Pirogov Russian National Research Medical University
Author for correspondence.
Email: vglinkina@mail.ru
Russian Federation, Moscow
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