Clinical efficiency of the integrated approach to the diagnosis and treatment of climacteric syndrome in the context of hypovitaminosis D

In our research we compared efficacy of menopausal hormone therapy and combination of menopausal hormone therapy with vitamin D in early postmenopause women with neurovegetative and psychoemotional signs of a menopausal syndrome with hypovitaminosis D. Aim of the stady was to prove a need of complex therapy of a menopausal syndrome in women with hypovitaminosis D using menopausal hormone therapy and сoleсaltsiferol to improve health, quality of life and prevent age-related diseases in early postmenopausal period. Materials and methods. Early postmenopausal period 90 female patients with neurovegetative and psychoemotional signs of a menopausal syndrome, who had blood 25(OH) D less 30 ng/ml and no contraindications of menopausal hormonal therapy were involved in this research. In all patients modified menopausal index of Kupperman was calculated. Depression was assessed with Beck's scale. Level of the hormonal status, C-peptide indicators and parathormone were detected initially, then in 3 and 12 months. Results. Menopausal hormone therapy in combination with vitamin D level corrected with сoleсaltsiferol in early menopause period women with climacteric symptoms contributed therapeutic effect showing decrease of seizures (p<0.001), drowsiness (p<0.001), muscular and joint pain (p<0.01), tiredness (p<0.001). Received results allowed to improve mood in our patients (p<0.05). Conclusion. Development of psychoemotional (asthenic, depressive) signs of menopausal syndrome, their expression depends on vitamin D level. Correction of a hypovitaminosis D before normalization of blood 25(OH)D level with сoleсaltsiferol in combination with menopausal hormone therapy allowed to receive statistically significant results in comparison with menopausal hormone therapy usage only (p<0.01).

menopause, vitamin D, colecalciferol, Kupperman's index, parathyroid hormone