Study of different pharmaceutical forms and pathogenic therapy regimen effectiveness for back and joint pain treatment in comorbid patients with osteoarthritis

Aim. To compare the safety and efficacy of using various dosage forms of chondroitin sulfate (CS) and glucose amino sulfate (G) in combination with low-intensity laser radiation (LILR) in patients with back pain and joints with comorbid pathology. Materials and methods. 86 patients (60 women and 20 men) aged 62.6±4.6 years with OA knee, hip joints and spondylosarthrosis. 48 patients were treated injecting forms of CS and G in combination with LILR. 20 patients with the same diagnosis and the same age category have had parenteral introduction of CS and G. 18 similar in pathology of patients took oral forms CS and G. Results and discussion. The significant improvement of subjective and objective condition of patients treated with parenteral CS+G and LILR already on 10-12 day of treatment is shown. The pain in the knee joints, lumbar spine decreased to Visual analogue scale (mm) 32% and amounted to 24.8±0.49 mm, whereas before the treatment of its values were 74.4±0.26 mm (p<0.05). On 25-28 observation day and three months later Intensity of pain syndrome continued to decrease significantly and was 18.8±1.12 (p<0.05). In the group, received parenteral therapy, joint pain has significantly decreased already on 10-12, 25-28 day and after 3 months of observation, but less significant when compared with the group 1, p<0.05. In group 3, treated only with oral forms of CS+G, the positive dynamics of this indicator was noted only after three months (p<0.05) and was accompanied by the development of side effects from the digestive organs. Conclusions. The significant advantage of therapy with parenteral forms of CS and G, caused by faster onset of anti-inflammatory and analgesic effect, absence of complications on the part of gastrointestinal tract is demonstrated. Combination of local influence of LILR with introduction of parenteral forms of CS and G has potentially and accelerated all listed effects of subjects of preparations.

osteoarthritis, spondylosarthrosis, chondroitin sulfate, Chondroguard, glucosamine, Sustaguard Artro, low-intensity laser radiation