Menopausal hormone therapy in the prevention of lipid metabolism disorders
- Authors: Podzolkova N.M.1, Podzolkov V.I.2, Tarzimanova A.I.2
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Affiliations:
- Russian Medical Academy of Continuous Professional Education
- Sechenov First Moscow State Medical University (Sechenov University)
- Issue: Vol 21, No 6 (2019)
- Pages: 81-85
- Section: Articles
- URL: https://bakhtiniada.ru/2075-1753/article/view/96855
- DOI: https://doi.org/10.26442/20751753.2019.6.190557
- ID: 96855
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Abstract
Cardiovascular disease is the leading cause of mortality in older women. The progression of these diseases in women is closely related to a natural processes of reproductive function decline. Estrogen deficiency which occurs in postmenopausal women contributes to lipid metabolism disorders: a decrease in anti-atherogenic HDL levels and an increase in levels of pro-atherogenic LDL, especially lipoprotein (a). Currently, there is evidence that menopausal hormone therapy (MHT) can have cardioprotective efficacy, provided that it begins at a time close to the onset of menopause. Randomized clinical trials proved a high efficacy of MHT for the prevention of atherosclerosis in early postmenopausal women. Individualization of MHT, i.e., selection of estrogen and progestogen components, their dose and route of administration which are optimal for a particular woman, is of great importance. The most significant cardioprotective effect of MHT has been proven for the combination of 17b-estradiol and dydrogesterone. One of modern drugs for combined MHT is Femoston®, which exerts beneficial effect on lipid metabolism and reduces insulin resistance.
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##article.viewOnOriginalSite##About the authors
Nataliya M. Podzolkova
Russian Medical Academy of Continuous Professional Education
Email: podzolkovа@gmail.com
D. Sci. (Med.), Prof. Moscow, Russia
Valerii I. Podzolkov
Sechenov First Moscow State Medical University (Sechenov University)
Email: podzolkov@list.ru
D. Sci. (Med.), Prof. Moscow, Russia
Aida I. Tarzimanova
Sechenov First Moscow State Medical University (Sechenov University)
Email: tarzimanova@mail.ru
д-р мед. наук, проф. каф. факультетской терапии №2 Moscow, Russia
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