Genetic variations of morphine transporters: prevalence of polymorphisms of the ABCB1 gene among oncology patients of palliative profile
- Authors: Khaitovich E.D.1, Shikh E.V.1, Ibragimov A.N.2, Gergel M.A.2, Borisov A.S.2, Kazakov R.E.3
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Affiliations:
- I.M. Sechenov First Moscow State Medical University (Sechenov University)
- Moscow Multidisciplinary Center for Palliative Care, Moscow Healthcare Department
- Scientific Center for Expertise of Medical Products
- Issue: Vol 32, No 6 (2025)
- Pages: 182-188
- Section: Oncology
- URL: https://bakhtiniada.ru/2073-4034/article/view/350659
- DOI: https://doi.org/10.18565/pharmateca.2025.6.182-188
- ID: 350659
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Abstract
Objective: Assessment of the prevalence of clinically significant single nucleotide polymorphisms of the ABCB1 gene (rs1128503, rs2032582, rs1045642) in palliative cancer patients receiving morphine in order to substantiate the prospects of a pharmacogenetic approach to personalized analgesic therapy.
Materials and methods: The study included 86 patients with cancer in the palliative stage and receiving morphine, as well as 100 control patients without cancer. Genotyping of ABCB1 polymorphisms was performed using real-time polymerase chain reaction. The dynamics of pain syndrome was also assessed using a visual analog scale (VAS) at three stages of therapy.
Results: A high frequency of heterozygous CT variants for rs1128503 and rs1045642 polymorphisms was established. VAS analysis showed a decrease in pain syndrome from 8 to 2 points after the start of morphine therapy, which confirms its effectiveness.
Conclusion: ABCB1 gene polymorphisms may play a significant role in the variability of response to morphine in cancer patients. The obtained data emphasize the need for further research to develop personalized pain relief strategies taking into account genetic characteristics.
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##article.viewOnOriginalSite##About the authors
Evgeny D. Khaitovich
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Author for correspondence.
Email: eukhad@gmail.com
ORCID iD: 0000-0003-2629-9250
Postgraduate Student, Department of Clinical Pharmacology and Propaedeutics of Internal Medicine, Clinical Pharmacologist
Russian Federation, MoscowEvgenia V. Shikh
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Email: chih@mail.ru
ORCID iD: 0000-0001-6589-7654
Dr. Sci. (Med.), Professor, Corr. Member of the RAS, Head of the Department of Clinical Pharmacology and Propaedeutics of Internal Medicine
Russian Federation, MoscowArif N. Ibragimov
Moscow Multidisciplinary Center for Palliative Care, Moscow Healthcare Department
Email: eukhad@gmail.com
Chief Physician
Russian Federation, MoscowMark A. Gergel
Moscow Multidisciplinary Center for Palliative Care, Moscow Healthcare Department
Email: eukhad@gmail.com
Palliative Care Physician
Russian Federation, MoscowAnton S. Borisov
Moscow Multidisciplinary Center for Palliative Care, Moscow Healthcare Department
Email: eukhad@gmail.com
Palliative Care Physician
Russian Federation, MoscowRuslan E. Kazakov
Scientific Center for Expertise of Medical Products
Email: eukhad@gmail.com
ORCID iD: 0000-0003-0802-4229
Cand. Sci. (Biol.), Leading Researcher
Russian Federation, MoscowReferences
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