Combination of diffuse toxic goiter and connective tissue disease (clinical observation)
- Authors: Sharonova L.A.1, Bulgakova S.V.1, Kosareva O.V.1, Dolgikh Y.A.1, Merzlova P.Y.1, Treneva E.V.1, Kurmaev D.P.1
-
Affiliations:
- Samara State Medical University
- Issue: Vol 32, No 2 (2025)
- Pages: 136-143
- Section: Clinical case
- URL: https://bakhtiniada.ru/2073-4034/article/view/294231
- DOI: https://doi.org/10.18565/pharmateca.2025.2.136-143
- ID: 294231
Cite item
Open Access
Access granted
Subscription Access
Abstract
The relationship between thyroid diseases and various systemic connective tissue disorders has been known for a long time, including the association of systemic scleroderma and scleroderma-like fibrosing skin lesions with thyroid diseases. However, the literature mainly describes cases of a combination of connective tissue diseases with hypothyroidism against the background of chronic autoimmune thyroiditis. The authors describe a clinical case of associated course of diffuse toxic goiter complicated by endocrine ophthalmopathy and connective tissue disease lasting 14 years. The article discusses the difficulties of diagnosis and choice of treatment tactics for such a patient. A multidisciplinary approach to managing a patient with combined autoimmune pathology of the thyroid gland and connective tissue can increase the effectiveness of treatment and improve the long-term prognosis.
Full Text
##article.viewOnOriginalSite##About the authors
Lyudmila A. Sharonova
Samara State Medical University
Author for correspondence.
Email: l.a.sharonova@samsmu.ru
ORCID iD: 0000-0001-8827-4919
Cand. Sci. (Med.), Associate Professor, Department of Endocrinology and Geriatrics
Russian Federation, SamaraSvetlana V. Bulgakova
Samara State Medical University
Email: osteoporosis63@gmail.com
ORCID iD: 0000-0003-0027-1786
Dr. Sci. (Med.), Associate Professor, Head of the Department of Endocrinology and Geriatrics
Russian Federation, SamaraOlga V. Kosareva
Samara State Medical University
Email: o.v.kosareva@samsmu.ru
ORCID iD: 0009-0006-4531-9682
Cand. Sci. (Med.), Associate Professor, Department of Endocrinology and Geriatrics
Russian Federation, SamaraYulia A. Dolgikh
Samara State Medical University
Email: yu.a.dolgikh@samsmu.ru
ORCID iD: 0000-0001-6678-6411
Cand. Sci. (Med.), Assistant Professor, Department of Endocrinology and Geriatrics
Russian Federation, SamaraPolina Ya. Merzlova
Samara State Medical University
Email: p.ya.merzlova@samsmu.ru
ORCID iD: 0009-0004-6243-6528
Assistant, Department of Endocrinology and Geriatrics
Russian Federation, SamaraEkaterina V. Treneva
Samara State Medical University
Email: eka1006@yandex.ru
ORCID iD: 0000-0003-0097-7252
Cand. Sci. (Med.), Associate Professor, Department of Endocrinology and Geriatrics
Russian Federation, SamaraDmitry P. Kurmaev
Samara State Medical University
Email: geriatry@mail.ru
ORCID iD: 0000-0003-4114-5233
Assistant, Department of Endocrinology and Geriatrics
Russian Federation, SamaraReferences
- Санеева Г.А. Структура и клиническое значение тиреоидной патологии в аспекте дисплазии соединительной ткани при гипермобильном синдроме. Международный научно-исследовательский журнал. 2017;1(55):160–3. [Saneeva G.A. Structure and clinical significance of thyroid pathology in case of tissue dysplasia and hpermobility syndrome. Int Res J. 2017;1(55):160–3. (In Russ.)]. doi: 10.23670/IRJ.2017.55.042.
- Подчерняева Н.С., Бокарева Е.И., Витебская А.В. Аутоиммунная патология щитовидной железы у больных ювенильной склеродермией. Педиатрия. Журнал им. Г. Н. Сперанского. 2015;94(5):19–25. [Podchernyaeva N.S., Bokareva E.I., Vitebskaya A.V. Autoimmune pathology of thyroid gland in patients with juvenile scleroderma. Pediatrics. Journal named after G. N. Speransky. 2015;94(5):19–25. (In Russ.)].
- Bagherzadeh-Fard M., Yazdanifar M.A., Aghaali M., Masoumi M. The prevalence of thyroid dysfunction and autoimmune thyroid disease in patients with rheumatoid arthritis. BMC. Rheumatol. 2022;6(1):63. doi: 10.1186/s41927-022-00293-9.
- Baldini C., Ferro F., Mosca M., et al. The Association of Sjögren Syndrome and Autoimmune Thyroid Disorders. Front. Endocrinol. 2018;9:121. doi: 10.3389/fendo.2018.00121.
- Чотчаева Ф.Р., Зыкова А.С., Новиков П.И., Моисеев С.В. Диагностика и лечение системной склеродермии. Клиническая фармакология и терапия. 2018;27(1):66–73. [Chotchaeva F.P., Zykova A.S., Novikov P.I., Moiseev S.V. Diagnosis and treatment of systemic sclerosis Clin Pharmacol Ther. 2018;27(1):66–73. (In Russ.)].
- Ferreli C., Gasparini G., Parodi A., et al. Cutaneous Manifestations of Scleroderma and Scleroderma-Like Disorders: a Comprehensive Review. Clin Rev Allergy Immunol. 2017;53(3):306–36. doi: 10.1007/s12016-017-8625-4.
- Toki S., Motegi S., Yamada K., et al. Demographic and clinical features of autoimmune thyroid disorder in Japanese patients with systemic sclerosis. J Dermatol. 2014;41(12):1053–7.
- Costa C.C., Medeiros M., Watanabe K., et al. Hashimoto thyroiditis may be associated with a subset of patients with systemic sclerosis with pulmonary hypertension. Rev Bras Reumatol. 2014;54(5):366–70.
- Antonelli A., Fallahi P., Ferrari S.M., et al. Incidence of thyroid disorders in syste-mic sclerosis: results from a longitudinal follow-up. J Сlin Endocrinol Metab. 2013;98(7):1198–202.
- Elhai M., Avouac J., Kahan A., Allanore Y. Systemic sclerosis at the crossroad of polyautoimmunity. Autoimmune Rev. 2013;12(11):1052–7.
- Nicholson D., White S., Lipson A., et al. Progressive systemic sclerosis and Graves’ disease. Report of three cases. Arch Intern Med. 1986;146(12):2350–2.
- Yu M.G., Quisumbing J.P. Limited cutaneous systemic sclerosis arising in a patient with Graves’ disease. BMJ. Case Rep. 2017;2017:bcr2016218808. doi: 10.1136/bcr-2016-218808.
- Шуваева Ф.К., Ворожцова Е.И., Вербовой А.Ф. Сочетание диффузно-узлового токсического зоба и склеродермы Бушке. Проблемы эндокринологии. 2011;57(6):27–9. [Shu-vaeva F.K., Vorozhtsova E.I., Verbovoy A.F. A case of diffuse toxic goiter and concomitant Buschke’s scleroderma. Problemy Endocrinol. 2011;57(6):27–9. (In Russ.)]. doi: 10.14341/probl201157627-29.
- Pournazari M., Mohamadzadeh D., Assar S., et al. Treatment of scleredema adultorum of Buschke with intravenous immunoglobulin and mycophenolate mofetil in a 14-year-old girl: a case report. J Med Case Reports. 2024;18:93. doi: 10.1186/s13256-024-04427-0.
- Ioannidou D.I., Krasagakis K., Stefanidou M.P., et al. Scleredema adultorum of Buschke presenting as periorbital edema: a diagnostic challenge. J Am Acad Dermatol. 2005;52(2 Suppl. 1):41–4. doi: 10.1016/j.jaad.2004.06.037.
- Шеремета М.С., Трухин А.А., Ярцев В.Д. и др. Слезный аппарат как орган риска при проведении радионуклидной терапии. Проблемы эндокринологии. 2024;70(1):13–7. [Sheremeta M.S., Trukhin A.A., Yartsev V.D., et al. The lacrimal apparatus as an organ at risk during radionuclide therapy. Problemy Endocrinol. 2024;70(1):13–7. (In Russ.)]. doi: 10.14341/probl13163.
- Дубровина Е.И., Гайдук И.В., Мкртумян А.М. и др. Постлучевые поражения слюнных желез после проведенной радиойодтерапии: особенности клинического течения. Медицинский алфавит. 2024;(1):63–7. [Dubrovina E.I., Gaiduk I.V., Mkrtumyan A.M., et al. Post-radiation lesions of the salivary glands after radioiodine therapy: features of the clinical course. Med Alphabet. 2024;(1):63–7. (In Russ.)]. doi: 10.33667/2078-5631-2024-1-63-67.
Supplementary files
