Regional experience with universal screening for total cholesterol in children
- 作者: Sadykova D.I.1, Kamalova A.A.1,2, Rakhmaeva R.F.1,2, Makarova T.P.1, Melnikova Y.S.1, Galimova L.F.1,2, Slastnikova E.S.1,2, Mustafaeva A.A.2, Petrova M.A.1,2, Garipova A.A.1, Kalistratova Y.A.1, Shtyrkova A.V.1, Sеnеk S.А.2
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隶属关系:
- Kazan State Medical University
- Children’s Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan
- 期: 卷 30, 编号 4/5 (2023)
- 页面: 104-108
- 栏目: Original articles
- URL: https://bakhtiniada.ru/2073-4034/article/view/275538
- DOI: https://doi.org/10.18565/pharmateca.2023.4-5.104-108
- ID: 275538
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详细
Background. The prevalence of risk factors for cardiovascular disease (CVD) is rapidly increasing. The world has accumulated clinical experience in screening for the detection of lipid metabolism disorders, but such studies have not been conducted in children in Russia.
Objective. Determination of the risk groups for the development of CVD among children based on the assessment of the hereditary factor, the level of physical development and blood total cholesterol (TC).
Methods. A cross-sectional study was conducted in 542 children aged 10 years (49% of boys and 51% of girls), and included signing of informed consent, questionnaires, study of child’s record, anthropometry with WHO AnthroPlus assessment, blood pressure measurement, determination of TC level by MultiCare-in express method (Italy).
Results. According to the survey data, risk factors included the presence in second-line relatives: myocardial infarction – in 15% of children, stroke – in 19%, arterial hypertension – in 40%, excess body weight – in 24%, diabetes mellitus – in 22%, vascular surgery heart and head - in 9%, smoking – in 63%. Nutritional disorders were revealed in 48% of children: underweight in 21% of children, overweight in 17%, obesity in 10%. In 35% of children, an increased TC level was determined. A high TC level was detected both in children with underweight and in children with overweight and obesity. In 7% of children (n=38), systolic blood pressure was above the 90% percentile.
Conclusion. Risk groups for the development of CVD were identified, including children with an elevated TC level, systolic blood pressure above the 90% percentile, and nutritional status disorders. A high TC level in children with normal physical development dictates the need for a more detailed assessment of the nutritional status with the determination of the component composition of the body. Children with a capillary TC level of more than 5.2 mmol/L should be examined for TC in venous blood; and a differential diagnosis of primary and secondary genesis of dyslipidemia should be made.
作者简介
D. Sadykova
Kazan State Medical University
Email: aelitakamalova@gmail.com
ORCID iD: 0000-0002-6662-3548
俄罗斯联邦, Kazan
Aelita Kamalova
Kazan State Medical University; Children’s Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan
编辑信件的主要联系方式.
Email: aelitakamalova@gmail.com
ORCID iD: 0000-0002-2957-680X
Dr. Sci. (Med.), Professor, Department of Hospital Pediatrics, Physician
俄罗斯联邦, Kazan; KazanR. Rakhmaeva
Kazan State Medical University; Children’s Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan
Email: aelitakamalova@gmail.com
ORCID iD: 0000-0001-6107-2233
俄罗斯联邦, Kazan; Kazan
T. Makarova
Kazan State Medical University
Email: aelitakamalova@gmail.com
ORCID iD: 0000-0002-5722-8490
俄罗斯联邦, Kazan
Yu. Melnikova
Kazan State Medical University
Email: aelitakamalova@gmail.com
ORCID iD: 0000-0001-6633-6381
俄罗斯联邦, Kazan
L. Galimova
Kazan State Medical University; Children’s Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan
Email: aelitakamalova@gmail.com
ORCID iD: 0000-0001-5576-5279
俄罗斯联邦, Kazan; Kazan
E. Slastnikova
Kazan State Medical University; Children’s Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan
Email: aelitakamalova@gmail.com
ORCID iD: 0000-0002-1732-7443
俄罗斯联邦, Kazan; Kazan
A. Mustafaeva
Children’s Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan
Email: aelitakamalova@gmail.com
ORCID iD: 0000-0001-5609-135X
俄罗斯联邦, Kazan
M. Petrova
Kazan State Medical University; Children’s Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan
Email: aelitakamalova@gmail.com
俄罗斯联邦, Kazan; Kazan
A. Garipova
Kazan State Medical University
Email: aelitakamalova@gmail.com
ORCID iD: 0000-0002-5938-7401
俄罗斯联邦, Kazan
Yu. Kalistratova
Kazan State Medical University
Email: aelitakamalova@gmail.com
ORCID iD: 0009-0006-4692-2459
俄罗斯联邦, Kazan
A. Shtyrkova
Kazan State Medical University
Email: aelitakamalova@gmail.com
ORCID iD: 0000-0002-1930-3234
俄罗斯联邦, Kazan
S. Sеnеk
Children’s Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan
Email: aelitakamalova@gmail.com
ORCID iD: 0000-0003-3822-4600
俄罗斯联邦, Kazan
参考
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