Application of reporter strains for screening of new antibiotics
- Авторы: Sergiev P.V.1, Osterman I.A.1, Golovina A.Y.1, Andreyanova E.S.2, Laptev I.G.1, Pletnev P.I.1, Evfratov S.A.1, Marusich E.I.3, Leonov S.V.3, Ivanenkov Y.A.3, Bogdanov A.A.1, Dontsova O.A.1
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Учреждения:
- Department of Chemistry and Belozersky Institute of Physico-Chemical Biology
- Faculty of Bioengineering and Bioinformatics
- Moscow Institute of Physics and Technology
- Выпуск: Том 10, № 4 (2016)
- Страницы: 293-299
- Раздел: Article
- URL: https://bakhtiniada.ru/1990-7508/article/view/197509
- DOI: https://doi.org/10.1134/S1990750816040065
- ID: 197509
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Аннотация
Screening for new antibiotics remains an important area of biology and medicine. Elucidation of the antibiotic mechanism of action is an indispensable part for this type of research. Preferentially, it should be carried out quickly and cost-effectively, on the stage of primary screening. In this review we describe application of reporter strains for rapid classification of antibiotics by their mechanisms of action, without prior purification of active compounds and determination of their chemical structure.
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Об авторах
P. Sergiev
Department of Chemistry and Belozersky Institute of Physico-Chemical Biology
Автор, ответственный за переписку.
Email: petya@genebee.msu.ru
Россия, Moscow, 119992
I. Osterman
Department of Chemistry and Belozersky Institute of Physico-Chemical Biology
Email: petya@genebee.msu.ru
Россия, Moscow, 119992
A. Golovina
Department of Chemistry and Belozersky Institute of Physico-Chemical Biology
Email: petya@genebee.msu.ru
Россия, Moscow, 119992
E. Andreyanova
Faculty of Bioengineering and Bioinformatics
Email: petya@genebee.msu.ru
Россия, Moscow, 119992
I. Laptev
Department of Chemistry and Belozersky Institute of Physico-Chemical Biology
Email: petya@genebee.msu.ru
Россия, Moscow, 119992
P. Pletnev
Department of Chemistry and Belozersky Institute of Physico-Chemical Biology
Email: petya@genebee.msu.ru
Россия, Moscow, 119992
S. Evfratov
Department of Chemistry and Belozersky Institute of Physico-Chemical Biology
Email: petya@genebee.msu.ru
Россия, Moscow, 119992
E. Marusich
Moscow Institute of Physics and Technology
Email: petya@genebee.msu.ru
Россия, Dolgoprudnyi, Moscow region, 117303
S. Leonov
Moscow Institute of Physics and Technology
Email: petya@genebee.msu.ru
Россия, Dolgoprudnyi, Moscow region, 117303
Ya. Ivanenkov
Moscow Institute of Physics and Technology
Email: petya@genebee.msu.ru
Россия, Dolgoprudnyi, Moscow region, 117303
A. Bogdanov
Department of Chemistry and Belozersky Institute of Physico-Chemical Biology
Email: petya@genebee.msu.ru
Россия, Moscow, 119992
O. Dontsova
Department of Chemistry and Belozersky Institute of Physico-Chemical Biology
Email: petya@genebee.msu.ru
Россия, Moscow, 119992
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