Email this article Application of reporter strains for screening of new antibiotics
- Authors: Sergiev P.V.1, Osterman I.A.1, Golovina A.Y.1, Andreyanova E.S.2, Laptev I.G.1, Pletnev P.I.1, Evfratov S.A.1, Marusich E.I.3, Leonov S.V.3, Ivanenkov Y.A.3, Bogdanov A.A.1, Dontsova O.A.1
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Affiliations:
- Department of Chemistry and Belozersky Institute of Physico-Chemical Biology
- Faculty of Bioengineering and Bioinformatics
- Moscow Institute of Physics and Technology
- Issue: Vol 10, No 4 (2016)
- Pages: 293-299
- Section: Article
- URL: https://bakhtiniada.ru/1990-7508/article/view/197509
- DOI: https://doi.org/10.1134/S1990750816040065
- ID: 197509
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Abstract
Screening for new antibiotics remains an important area of biology and medicine. Elucidation of the antibiotic mechanism of action is an indispensable part for this type of research. Preferentially, it should be carried out quickly and cost-effectively, on the stage of primary screening. In this review we describe application of reporter strains for rapid classification of antibiotics by their mechanisms of action, without prior purification of active compounds and determination of their chemical structure.
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About the authors
P. V. Sergiev
Department of Chemistry and Belozersky Institute of Physico-Chemical Biology
Author for correspondence.
Email: petya@genebee.msu.ru
Russian Federation, Moscow, 119992
I. A. Osterman
Department of Chemistry and Belozersky Institute of Physico-Chemical Biology
Email: petya@genebee.msu.ru
Russian Federation, Moscow, 119992
A. Ya. Golovina
Department of Chemistry and Belozersky Institute of Physico-Chemical Biology
Email: petya@genebee.msu.ru
Russian Federation, Moscow, 119992
E. S. Andreyanova
Faculty of Bioengineering and Bioinformatics
Email: petya@genebee.msu.ru
Russian Federation, Moscow, 119992
I. G. Laptev
Department of Chemistry and Belozersky Institute of Physico-Chemical Biology
Email: petya@genebee.msu.ru
Russian Federation, Moscow, 119992
P. I. Pletnev
Department of Chemistry and Belozersky Institute of Physico-Chemical Biology
Email: petya@genebee.msu.ru
Russian Federation, Moscow, 119992
S. A. Evfratov
Department of Chemistry and Belozersky Institute of Physico-Chemical Biology
Email: petya@genebee.msu.ru
Russian Federation, Moscow, 119992
E. I. Marusich
Moscow Institute of Physics and Technology
Email: petya@genebee.msu.ru
Russian Federation, Dolgoprudnyi, Moscow region, 117303
S. V. Leonov
Moscow Institute of Physics and Technology
Email: petya@genebee.msu.ru
Russian Federation, Dolgoprudnyi, Moscow region, 117303
Ya. A. Ivanenkov
Moscow Institute of Physics and Technology
Email: petya@genebee.msu.ru
Russian Federation, Dolgoprudnyi, Moscow region, 117303
A. A. Bogdanov
Department of Chemistry and Belozersky Institute of Physico-Chemical Biology
Email: petya@genebee.msu.ru
Russian Federation, Moscow, 119992
O. A. Dontsova
Department of Chemistry and Belozersky Institute of Physico-Chemical Biology
Email: petya@genebee.msu.ru
Russian Federation, Moscow, 119992
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