电邮这篇文章 Inhibin B in diagnosis and monitoring of granulosa-cell tumors of ovary
- 作者: Lyubimova N.V.1, Beishembaev A.M.2, Timofeev Y.S.1, Zhordania K.I.1, Kushlinskii N.E.1
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隶属关系:
- Blokhin National Medical Research Centre of Oncology
- Daniyarov Kyrgyz State Medical Institute of Re-education and Preferment Qualification
- 期: 卷 22, 编号 2 (2020)
- 页面: 116-118
- 栏目: Review
- URL: https://bakhtiniada.ru/1815-1434/article/view/34965
- DOI: https://doi.org/10.26442/18151434.2020.2.200121
- ID: 34965
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Introduction. Granulosa cell tumors of ovary (GCTO) – rare type of malignant ovarian neoplasms formed from granulosa cells of the follicles capable to produce biologically active substances, including inhibin B. The purpose of this study is evaluation of clinical significance of inhibin B analysis in blood serum of patients with adult type of GCTO primary disease, relapse and during remission after treatment.
Materials and methods. The study included 134 patients with GCTO, 15 patients with benign ovarian tumors and 82 healthy women. Inhibin B was determined in blood serum with standard enzyme-linked immunosorbent assay Inhibin B Gen II ELISA (Beckman Coulter, USA) in the microplate format.
Results. The analysis data indicates a high sensitivity of inhibin B in the diagnosis of primary GCTO (92.3%) and in relapse (92.7%) with a specificity 100%. An increase of inhibin B before the clinical manifestation of relapse (for 2–12 months) confirms its significance as an effective biochemical marker for GCTO monitoring.
Conclusion. Inhibin B can be used as effective biochemical marker of primary and GCTO and its relapses.
作者简介
Nina Lyubimova
Blokhin National Medical Research Centre of Oncology
编辑信件的主要联系方式.
Email: biochimia@yandex.ru
ORCID iD: 0000-0003-0430-2754
D. Sci. (Biol.), Prof.
俄罗斯联邦, MoscowAlmaz Beishembaev
Daniyarov Kyrgyz State Medical Institute of Re-education and Preferment Qualification
Email: biochimia@yandex.ru
Cand. Sci. (Med.)
吉尔吉斯斯坦, BishkekYurii Timofeev
Blokhin National Medical Research Centre of Oncology
Email: biochimia@yandex.ru
Cand. Sci. (Med.)
俄罗斯联邦, MoscowKirill Zhordania
Blokhin National Medical Research Centre of Oncology
Email: biochimia@yandex.ru
D. Sci. (Med.), Prof.
俄罗斯联邦, MoscowNikolai Kushlinskii
Blokhin National Medical Research Centre of Oncology
Email: biochimia@yandex.ru
ORCID iD: 0000-0002-3898-4127
D. Sci. (Med.), Prof., Acad. RAS
俄罗斯联邦, Moscow参考
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