Отправить статью по E-mail Выбор антиангиогенного препарата во 2-й линии терапии больных метастатическим раком толстой кишки: бевацизумаб, афлиберцепт, рамуцирумаб (обзор литературы)
- Авторы: Федянин М.Ю.1
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Учреждения:
- ФГБУ Российский онкологический научный центр им. Н.Н.Блохина Минздрава России
- Выпуск: Том 17, № 3 (2015)
- Страницы: 81-87
- Раздел: Статьи
- URL: https://bakhtiniada.ru/1815-1434/article/view/27035
- ID: 27035
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Аннотация
За последнее десятилетие возможности лекарственной терапии больных метастатическим раком толстой кишки (мРТК) расширились за счет появления таргетных препаратов, большинство из которых обладают антиангиогенным действием (бевацизумаб, афлиберцепт, рамуцирумаб, регорафениб). Одним из вариантов стандартной терапии больных в 1-й линии является комбинация химиопрепаратов и бевацизумаба, особенно у лиц с мутацией в генах EGFR-сигнального пути. Однако у большинства пациентов рано или поздно разовьется прогрессирование, и нельзя однозначно сказать, что следует назначать больному во 2-й линии лечения. Именно сложности выбора последовательности терапии у лиц с мРТК в случае назначения антиангиогенных препаратов в 1-й линии терапии и посвящен настоящий обзор.
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Михаил Юрьевич Федянин
ФГБУ Российский онкологический научный центр им. Н.Н.Блохина Минздрава России
Email: Fedianinmu@mail.ru
канд. мед. наук, врач-онколог отд-ния клин. фармакологии и химиотерапии ФГБУ РОНЦ им. Н.Н.Блохина 115478, Россия, Москва, Каширское ш., д. 23
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