Trace elements and the inflammatory process development: predictive possibilities
- Авторлар: Morozova G.D.1, Logvinenko A.A.2, Grabeklis A.R.1,3, Nikolaev S.E.3, Sadykov A.R.4, Yurasov V.V.3,4, Skalny A.V.1,3
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Мекемелер:
- I.M. Sechenov First Moscow State Medical University (Sechenov University)
- Private healthcare institution «Central clinical hospital «RZD-Medicine»
- Peoples Friendship University of Russia
- Laboratory of metabolomic diagnostics
- Шығарылым: Том 22, № 1 (2024)
- Беттер: 29-34
- Бөлім: Original research
- URL: https://bakhtiniada.ru/1728-2918/article/view/252225
- DOI: https://doi.org/10.29296/24999490-2024-01-04
- ID: 252225
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Аннотация
Introduction. Late diagnosis of inflammatory pathologies leads to increased risks of chronicization of the process, generalization, development of complications, and reduced effectiveness of therapy. Routine methods of clinical laboratory diagnostics often have diagnostic value at the stage of already developed disease with pronounced clinical manifestations. Determination of blood serum trace elements may have prognostic value in the diagnosis of inflammatory diseases. The trace elements most extensively studied in the context of inflammation and immune defense are copper and zinc.
The aim of the study. The aim of the study was to investigate the prognostic significance of determining copper and zinc concentrations in serum in the diagnosis of inflammation.
Material and methods. Concentrations of CRP, ferritin, ceruloplasmin, leukocytes, neutrophils, fibrinogen, copper, and zinc were determined in 1153 examined people aged 18 to 86 years. Serum trace elements were determined by ICP-MS method, the rest of the parameters were measured by standard methods. ROC analysis was used to evaluate the prognostic significance of serum copper and zinc measurements. Positive predictive value and negative predictive value were also calculated for the laboratory tests.
Results. It was shown that serum copper concentration in both men and women can be used as a predictor of abnormalities of CRP, ceruloplasmin, and fibrinogen. By abnormalities in serum copper concentration, it is possible to predict increased leukocytes in men and women; decreased leukocytes in men; and increased neutrophil levels in men and women. The prognostic significance of the laboratory test for serum zinc was found in relation to the detection of ferritin deficiency in women and ceruloplasmin deficiency in men and women.
Conclusion. The results obtained in the study suggest the possible use of serum copper and zinc laboratory tests for prognostic purposes.
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##article.viewOnOriginalSite##Авторлар туралы
Galina Morozova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Хат алмасуға жауапты Автор.
Email: morozova_g_d@staff.sechenov.ru
ORCID iD: 0000-0001-8600-902X
laboratory assistant
Ресей, MoscowAnna Logvinenko
Private healthcare institution «Central clinical hospital «RZD-Medicine»
Email: lgvnnk@mail.ru
ORCID iD: 0000-0002-9788-998X
biologist of the clinical diagnostic laboratory
Ресей, MoscowAndrei Grabeklis
I.M. Sechenov First Moscow State Medical University (Sechenov University); Peoples Friendship University of Russia
Email: andrewgrabeklis@gmail.com
ORCID iD: 0000-0003-4017-4139
Head of the Laboratory of Elementology and Human Ecology, Leading researcher
Ресей, Moscow; MoscowSemen Nikolaev
Peoples Friendship University of Russia
Email: nikolaev_se@pfur.ru
ORCID iD: 0009-0008-3114-9971
laboratory researcher at the Department of Medical Elementology
Ресей, MoscowArsenii Sadykov
Laboratory of metabolomic diagnostics
Email: arsenysadykov91@gmail.com
ORCID iD: 0000-0003-1269-0427
Data analyst
Ресей, MoscowVasiliy Yurasov
Peoples Friendship University of Russia; Laboratory of metabolomic diagnostics
Email: v.yurasov@lab4p.ru
ORCID iD: 0000-0002-2320-9806
Medical Affairs Director, Senior Lecturer of Department of Medical Elementology, Candidate of Medical Sciences
Ресей, Moscow; MoscowAnatoly Skalny
I.M. Sechenov First Moscow State Medical University (Sechenov University); Peoples Friendship University of Russia
Email: skalny.sport@gmail.com
ORCID iD: 0000-0001-7838-1366
Head of the Center for Bioelementology and Human Ecology, Head of Department of Medical Elementology, Doctor of Medical Sciences, Professor
Ресей, Moscow; MoscowӘдебиет тізімі
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