Email this article Chronic hepatitis C: from long-term incidence changes to assessment of potential years of life lost (repeated cross-sectional studies)
- Authors: Sotskov A.Y.1, Isaeva N.V.1, Voronova E.A.1
-
Affiliations:
- Academician Ye.A. Vagner Perm State Medical University
- Issue: Vol 24, No 3 (2025)
- Pages: 179-184
- Section: SOCIOLOGY OF HEALTH AND DISEASE
- URL: https://bakhtiniada.ru/1728-2810/article/view/363343
- DOI: https://doi.org/10.17816/socm683679
- EDN: https://elibrary.ru/XYNXUU
- ID: 363343
Cite item
Open Access
Access granted
Subscription Access
Abstract
BACKGROUND: Chronic hepatitis C (CHC) remains one of the leading causes of viral hepatitis in Russia and worldwide, creating a significant social and economic burden, especially in working-age groups. Years of Potential Life Lost (YPLL), which is rarely used in Russian studies, is a sensitive social significance indicator of the disease.
AIM: This study aimed to assess the long-term changes of CHC incidence and population health losses in the Perm Territory using the YPLL as an indicator of the social, demographic, and economic burden of the disease.
METHODS: An epidemiological study was conducted based on published statistics and reporting on the incidence of viral hepatitis for 1999–2024 provided by Rospotrebnadzor in the Perm Territory. The study included all registered cases of acute and chronic viral hepatitis and deaths from CHC during the that period. A standard age of 70 years was used to calculate the YPLL. The calculations used the adopted formula: YPLL = ∑di × ai. The data are standardized per 100,000 population. Statistical processing was performed in the Statistica 8.0 suite and data visualization was performed in Microsoft Excel 2007.
RESULTS: In 1999–2024, the incidence of CHC had three epidemic phases, including growth, stabilization, and decline. In 2024, the actual incidence rate (24.3 per 100,000 population) exceeded the upper limit of the curvilinear trend confidence interval by 65.3%, indicating epidemic levels of CHC. The YPLL ranged from 46.5 to 219.2 years per 100,000 population, peaking in 2012 and showing another increase in 2020–2021 amid the COVID-19 pandemic. In 2024, the average YPLL was 47.3 years per 100,000 population.
CONCLUSION: In the Perm Territory, CHC epidemic has intensified since 2022. The YYPL confirmed the continuing social and demographic burden of CHC in the Perm Territory, showing the need to intensify screening and preventive efforts.
About the authors
Artem Yu. Sotskov
Academician Ye.A. Vagner Perm State Medical University
Author for correspondence.
Email: Sozkov1998a@mail.ru
ORCID iD: 0000-0003-0225-2925
SPIN-code: 7289-3843
Russian Federation, Perm
Natalia V. Isaeva
Academician Ye.A. Vagner Perm State Medical University
Email: nvisaeva@list.ru
ORCID iD: 0009-0007-0626-7979
SPIN-code: 3423-6491
MD, Dr. Sci. (Medicine), Professor
Russian Federation, PermElena A. Voronova
Academician Ye.A. Vagner Perm State Medical University
Email: ve-6971@mail.ru
ORCID iD: 0000-0003-4465-7453
SPIN-code: 3933-6759
MD, Сand. Sci. (Medicine), Assistant Professor
Russian Federation, PermReferences
- Implementing the global health sector strategies on HIV, viral hepatitis and sexuallytransmitted infections, 2022–2030: report on progress and gaps 2024. Geneva: World Health Organization; 2024. ISBN: 978-92-4-009492-5
- Cui F, Blach S, Manzengo Mingiedi C, et al. Global reporting of progress towards elimination of hepatitis B and hepatitis C. Lancet Gastroenterol Hepatol. 2023;8(4):332–342. doi: 10.1016/S2468-1253(22)00386-7 EDN: ZSEXIC
- Peña-Longobardo LM, Oliva-Moreno J, Fernández-Rodriguez C. The effect of hepatitis C-associated premature deaths on labour productivity losses in Spain: a ten-year analysis. Eur J Health Econ. 2023;24(8):1271–1283. doi: 10.1007/s10198-022-01540-z EDN: QICCBK
- Nogoibaeva KA, Tobokalova ST, Boronbaeva EK. Years of potential life lost due to hepatitis b with or without delta agent in the kyrgyz republic. Russian journal of infection and immunity. 2024;14(2):331–338. doi: 10.15789/2220-7619-YOP-2129 EDN: LAKRZU
- Krasil'nikov IA, Ivanova AE, Semenova VG, et al. Methodological recommendations for the use of the "Years of Potential Life Lost" (YPLL) indicator to substantiate priority health issues for the Russian population at the federal, regional, and municipal levels. Moscow: RIO FGBU “TsNIIOIZ” Minzdrava Rossii; 2014. 32 p. Available from: https://mednet.ru/images/stories/files/materialy_konferencii_i_seminarov/2010/kadry2014/sessiya/metod.pdf (In Russ.)
- Mikhaylova YuV, Sterlikov SA, Gromov AV. Mortality from viral hepatitis in the russian federation (analytical review). Current problems of health care and medical statistics. 2022;(1):414–437. doi: 10.24412/2312-2935-2022-1-414-437 EDN: EQGDUZ
- Global progress report on HIV, viral hepatitis and sexually transmitted infections, 2021. Accountability for the global health sector strategies 2016–2021: actions for impact. Geneva: World Health Organization; 2021. ISBN: 978-92-4-002707-7
- Baptista-Leite R, Lopes H, Franco D, et al. Primary healthcare as a strategy for eliminating hepatitis C: the METRIC toolkit. Prim Health Care Res Dev. 2024;25:e61. doi: 10.1017/S1463423624000355 EDN: LXRUYD
- Yakusheva MB, Nebolsina AP, Charushina IP, et al. Treatment of chronic viral hepatitis c in Perm krai. Perm medical journal. 2023;40(6):31–39. doi: 10.17816/pmj40631-39 EDN: VISAJB
Supplementary files
