Synthesis of Novel Triazolyl Thiourea Derivatives and Their Antibacterial Activity


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4-Amino-5-methyl-2,4-dihydro-3H-1,2,4-triazole-3-thione was synthesized in three steps from carbon disulfide, hydrazine hydrate, and acetic acid. Its reaction with benzoyl isothiocyanates prepared from substituted benzoyl chlorides and ammonium thiocyanate afforded the corresponding N-benzoyl-N′-triazolyl-thioureas. The obtained compounds were screened for antibacterial activity against Staphylococcus aureus (ATCC 25923), Staphylococcus epidermidis (ATCC 12228), Enterococcus faecalis (ATCC 29212), Escherichia coli (ATCC 25922), and Pseudomonas aeruginosa (ATCC 27853). Their antibacterial activity against gram-positive bacteria was higher than against gram-negative bacteria, and derivatives containing electron-withdrawing groups were more active than those with electron-donating substituents.

作者简介

Z. Kazeminejad

Chemistry Department, Tonekabon Branch

Email: abolfazl.shiroudi@iauet.ac.ir
伊朗伊斯兰共和国, Tonekabon

K. Pourshamsian

Chemistry Department, Tonekabon Branch

编辑信件的主要联系方式.
Email: Kshams49@gmail.com
伊朗伊斯兰共和国, Tonekabon

F. Hatamjafari

Chemistry Department, Tonekabon Branch

Email: abolfazl.shiroudi@iauet.ac.ir
伊朗伊斯兰共和国, Tonekabon

A. Shiroudi

Young Researchers and Elite Club, East Tehran Branch

编辑信件的主要联系方式.
Email: abolfazl.shiroudi@iauet.ac.ir
伊朗伊斯兰共和国, Tehran

A. Oliaey

Chemistry Department, Tonekabon Branch

Email: abolfazl.shiroudi@iauet.ac.ir
伊朗伊斯兰共和国, Tonekabon

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