One-Pot Synthesis of 3,5-Disubstituted 1,2,4-Oxadiazoles Using Catalytic System NaOH‒DMSO

V. E. Pankrat’eva; T. V. Sharonova; M. V. Tarasenko; S. V. Baikov; E. R. Kofanov

doi:10.1134/S1070428018080213

One-Pot Synthesis of 3,5-Disubstituted 1,2,4-Oxadiazoles Using Catalytic System NaOH‒DMSO

作者: Pankrat’eva V.E.¹, Sharonova T.V.¹, Tarasenko M.V.², Baikov S.V.³, Kofanov E.R.²
隶属关系:
1. Transfer Center of Pharmaceutical Technology
2. Yaroslavl State Technical University
3. St. Petersburg State University
期: 卷 54, 编号 8 (2018)
页面: 1250-1255
栏目: Article
URL: https://bakhtiniada.ru/1070-4280/article/view/218760
DOI: https://doi.org/10.1134/S1070428018080213
ID: 218760

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详细

One-pot convenient process was developed for the production of 3,5-disubstituted 1,2,4-oxadiazoles by reaction of amidoximes with anhydrides or acyl chlorides in a system NaOH‒DMSO. The reaction proceeds at room temperature with high yields.