Reactions of Ethyl 2-Amino-5-(2-aryl-2-oxoethylidene)- 4-oxo-4,5-dihydrofuran-3-carboxylates and 2-Amino-5-(2-aryl- 2-oxoethylidene)-4-oxo-4,5-dihydrofuran-3-carbonitriles with Alcohols

D. V. Ivanov; N. M. Igidov; S. N. Shurov; M. V. Dmitriev; I. N. Chernov

doi:10.1134/S1070428018040097

Reactions of Ethyl 2-Amino-5-(2-aryl-2-oxoethylidene)- 4-oxo-4,5-dihydrofuran-3-carboxylates and 2-Amino-5-(2-aryl- 2-oxoethylidene)-4-oxo-4,5-dihydrofuran-3-carbonitriles with Alcohols

作者: Ivanov D.V.¹^,2, Igidov N.M.², Shurov S.N.¹, Dmitriev M.V.¹, Chernov I.N.³
隶属关系:
1. Perm National State Research University
2. Perm State Pharmaceutical Academy
3. Research Institute of Chemistry
期: 卷 54, 编号 4 (2018)
页面: 573-577
栏目: Article
URL: https://bakhtiniada.ru/1070-4280/article/view/217519
DOI: https://doi.org/10.1134/S1070428018040097
ID: 217519

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Ethyl 2-amino-5-(2-aryl-2-oxoethylidene)-4-oxo-1H-4,5-dihydrofuran-3-carboxylates and 2-amino- 5-(2-aryl-2-oxoethylidene)-4-oxo-1H-4,5-dihydrofuran-3-carbonitriles reacted with alcohols in the presence of a catalytic amount of concentrated aqueous HCl to give the corresponding 5-alkoxy-2-amino-5-(2-aryl-2- oxoethyl)-4-oxo-1H-4,5-dihydrofuran-3-carboxylic acid derivatives. A probable reaction mechanism was proposed on the basis B3LYP/6-311G(d) quantum chemical calculations.