Synthesis of ferrocenyl-containing heterocyclic derivatives of 5-(4-aminophenyl)-10,15,20-triphenylporphyrin for sonodynamic therapy

E. Yu. Osipova; A. N. Rodionov; Yu. A. Belousov; M. M. Il’in; A. L. Nikolaev; A. V. Gopin; S. E. Mazina; A. A. Simenel

doi:10.1134/S1070428016010243

Synthesis of ferrocenyl-containing heterocyclic derivatives of 5-(4-aminophenyl)-10,15,20-triphenylporphyrin for sonodynamic therapy

作者: Osipova E.Y.¹, Rodionov A.N.¹, Belousov Y.A.¹, Il’in M.M.¹, Nikolaev A.L.², Gopin A.V.², Mazina S.E.², Simenel A.A.¹^,3
隶属关系:
1. Nesmeyanov Institute of Organoelement Compounds
2. Faculty of Chemistry
3. “Moscow Institute of Steel and Alloys” National University of Science and Technology
期: 卷 52, 编号 1 (2016)
页面: 127-130
栏目: Article
URL: https://bakhtiniada.ru/1070-4280/article/view/213627
DOI: https://doi.org/10.1134/S1070428016010243
ID: 213627

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The condensation of 1-(ferrocenylalkyl)pyrazole-3-carbaldehydes with 4′-aminotetraphenylporphyrin, followed by reduction with NaBH(OAc)₃ in 1,2-dichloroethane, provides a convenient method for the synthesis of 5-{4-[({1-[1-(ferrocen-1-yl)alkyl]-5-methyl-1H-pyrazol-3-yl}methyl)amino]phenyl}-10,15,20-triphenylporphyrins which exhibit pronounced cytotoxicity against Staphylococcus aureus under ultrasonic irradiation.