Synthesis of Aminomethoxy Derivatives of 1-(Butylsulfanyl)alkanes


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Аннотация

Three-component Mannich-type condensation of equimolar amounts of 1-(butylsulfanyl)alkan-2-ols, formaldehyde, and secondary aliphatic and heterocyclic amines at 45–50°C (3–4 h) afforded 65–82% of previously unknown aminomethoxy derivatives which were characterized by elemental analyses and IR, 1H and 13C NMR, and mass spectra. Some of the synthesized compounds were tested for antimicrobial activity against gram negative, gram positive, and spore-bearing bacteria and yeast-like fungi; they showed a higher activity than commonly used antibacterial agents. Compounds containing cyclic amine fragments were more active than those obtained from aliphatic amines. The tested compounds were recommended for use as antimicrobial agents.

Авторлар туралы

I. Jafarov

Azerbaijan State Pedagogical University

Email: eldar_mamedbeyli@mail.ru
Әзірбайжан, Baku

E. Mammadbayli

Institute of Petrochemical Processes

Хат алмасуға жауапты Автор.
Email: eldar_mamedbeyli@mail.ru
Әзірбайжан, Baku

N. Jafarova

Azerbaijan State University of Oil and Industry

Email: eldar_mamedbeyli@mail.ru
Әзірбайжан, Baku

G. Talybov

Institute of Petrochemical Processes

Email: eldar_mamedbeyli@mail.ru
Әзірбайжан, Baku

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