Easy Strategy for the Synthesis of New 5,6-Dihydro-[1,2,4]triazolo[4,3-a][1,3,5]triazine Derivatives


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Abstract

New substituted 5,6-dihydro[1,2,4]triazolo[4,3-a][1,3,5]triazines were synthesized by cyclocondensation of N-alkyl(aryl)-N′-(4H-1,2,4-triazol-3-yl)ethan- and -propanimidamides with benzaldehyde or ethyl methyl ketone in the presence of p-toluenesulfonic acid in 1,4-dioxane under reflux. The reaction tolerated a broad substrate scope and provided good yields (43–64%). The structure of the newly synthesized compounds was confirmed by elemental analyses and IR, 1H and 13C NMR, and mass spectra.

About the authors

A. Hajri

Laboratory of Functional Physiology and Valuation of Bio-resources (UR17ES27), Higher Institute of Biotechnology of Béja

Author for correspondence.
Email: lazharhajri.fsb@gmail.com
Tunisia, Béja

L. Marzouki

Laboratory of Functional Physiology and Valuation of Bio-resources (UR17ES27), Higher Institute of Biotechnology of Béja

Email: lazharhajri.fsb@gmail.com
Tunisia, Béja

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