Email this article Synthesis and Properties of N-[R-Adamantan-1(2)-yl]-N′-(2-fluorophenyl)ureas—Target-Oriented Soluble Epoxide Hydrolase Inhibitors
- Authors: Burmistrov V.V.1, Butov G.M.1,2
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Affiliations:
- Volzhskii Polytechnic Institute (Branch)
- Volgograd State Technical University
- Issue: Vol 54, No 9 (2018)
- Pages: 1307-1312
- Section: Article
- URL: https://bakhtiniada.ru/1070-4280/article/view/218859
- DOI: https://doi.org/10.1134/S1070428018090063
- ID: 218859
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Abstract
2-Fluorophenyl isocyanate reacted with adamantan-1(2)-amines and their homologs in DMF to give 31–92% of the corresponding N,N′-disubstituted ureas that are target-oriented human soluble epoxide hydrolase (sEH) inhibitors. Introduction of a fluorine atom increases the sEH inhibitory activity by a factor of 4.5.
About the authors
V. V. Burmistrov
Volzhskii Polytechnic Institute (Branch)
Email: butov@volpi.ru
Russian Federation, ul. Engel’sa 42a, Volzhskii, Volgograd oblast, 404121
G. M. Butov
Volzhskii Polytechnic Institute (Branch); Volgograd State Technical University
Author for correspondence.
Email: butov@volpi.ru
Russian Federation, ul. Engel’sa 42a, Volzhskii, Volgograd oblast, 404121; pr. Lenina 28, Volgograd, 400005
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