Convenient synthesis of 1-norbornyl-5-R-1H-1,2,3-triazole-4-carboxylic acids


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Abstract

A convenient procedure was developed for the synthesis of 2-azidobicyclo[2.2.1]heptane whose click reaction with phenylacetylene afforded 1-(bicyclo[2.2.1]heptan-2-yl)-4-phenyl-1H-1,2,3-triazol, and its reactions with ethyl α-bromoacrylate and ethyl acetoacetate gave 1-(bicyclo[2.2.1]heptan-2-yl)-5-R-1H-1,2,3-triazole-4-carboxylic acids.

About the authors

N. T. Pokhodylo

Ivan Franko Lviv National University

Email: obushak@in.lviv.ua
Ukraine, ul. Kirilla i Mefodiya 6, Lviv, 79005

V. S. Matiichuk

Ivan Franko Lviv National University

Email: obushak@in.lviv.ua
Ukraine, ul. Kirilla i Mefodiya 6, Lviv, 79005

M. D. Obushak

Ivan Franko Lviv National University

Author for correspondence.
Email: obushak@in.lviv.ua
Ukraine, ul. Kirilla i Mefodiya 6, Lviv, 79005

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