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Synthetic Approaches to 15-Deoxy-Δ12,14-prostaglandin J2. A New Key Building Block Based on (3aR,6R,6aS)-6-Trimethylsilyl)-3,3a,6,6a-tetrahydro-1H-cyclopenta[c]furan-1-one


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Abstract

{(1S,4R,5R)-5-[tert-Butyl(dimethyl)silyloxymethyl]-4-hydroxycyclopent-2-en-1-yl}acetaldehyde, the key building block in a possible approach to 15-deoxy-Δ12,14-prostaglandin J2, has been synthesized starting from (3aR,6R,6aS)-6-(trimethylsilyl)-3,3a,6,6a-tetrahydro-1H-cyclopenta[c]furan-1-one.

About the authors

A. M. Gimazetdinov

Ufa Institute of Chemistry, Ufa Federal Research Center

Email: bioreg@anrb.ru
Russian Federation, Ufa, Bashkortostan

A. Z. Al’mukhametov

Ufa Institute of Chemistry, Ufa Federal Research Center

Email: bioreg@anrb.ru
Russian Federation, Ufa, Bashkortostan

M. S. Miftakhov

Ufa Institute of Chemistry, Ufa Federal Research Center

Author for correspondence.
Email: bioreg@anrb.ru
Russian Federation, Ufa, Bashkortostan

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