Recent Advances in C-O Bond Construction via C-H Activation

Abstract

The direct construction of C-O bond by C-H activation is a highly efficient and practical method for the synthesis of esters, ethers, and hydroxy compounds. As compared to the conventional method of mutual functional group conversion, the C-H activation method provides not only improved atomic economy and reduced number of synthetic steps but also greatly improved overall yield of multistep syntheses. Studies of C-H activation to construct C-O bonds are crucial in the field of organic synthesis and catalysis research, and they have already been one of the research hotspots in related fields. According to the current trends in the development of C-H activation, different reaction types and different reaction conditions are classified in this review, and the latest advances in C-H activation to form C-O bonds are discussed.