Synthesis of 5,8-Diamino-Substituted Pyrano[4″,3″:4′,5′]pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidines and Pyrimido[4′,5′:4,5]thieno[2,3-c]isoquinolines
- Authors: Paronikyan E.G.1, Dashyan S.S.1, Minasyan N.S.2, Stepanyan G.M.1
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Affiliations:
- Mndzhoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
- Molecular Structure Research Center, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
- Issue: Vol 52, No 4 (2016)
- Pages: 576-581
- Section: Review
- URL: https://bakhtiniada.ru/1070-4280/article/view/214177
- DOI: https://doi.org/10.1134/S1070428016040187
- ID: 214177
Cite item
Abstract
Ethyl 1-amino-8,8-dimethyl-5-(piperidin-1-yl)-8,9-dihydro-6H-pyrano[4,3-d]thieno[2,3-b]pyridine-2-carboxylate and ethyl 1-amino-5-(piperidin-1-yl)-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carboxylate reacted with benzoyl isothiocyanate to give the corresponding 1-thioureido derivatives which underwent cyclization to 2,2-dimethyl-5-(piperidin-1-yl)-10-thioxo-1,4,10,11-tetrahydro-2H-pyrano[4″,3″:4′,5′]pyrido-[3′,2′:4,5]thieno[3,2-d]pyrimidin-8(9H)-one and 5-(piperidin-1-yl)-10-thioxo-1,2,3,4,10,11-hexahydropyrimido-[4′,5′:4,5]thieno[2,3-c]isoquinolin-8(9H)-one. The cyclization products were converted into 8-chloro derivatives, and the chlorine atom therein was replaced by various amines.
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About the authors
E. G. Paronikyan
Mndzhoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: Shdashyan@gmail.com
Armenia, pr. Azatutyan 26, Yerevan, 0014
Sh. Sh. Dashyan
Mndzhoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Author for correspondence.
Email: Shdashyan@gmail.com
Armenia, pr. Azatutyan 26, Yerevan, 0014
N. S. Minasyan
Molecular Structure Research Center, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: Shdashyan@gmail.com
Armenia, pr. Azatutyan 26, Yerevan, 0014
G. M. Stepanyan
Mndzhoyan Institute of Fine Organic Chemistry, Scientific and Technological Center of Organic and Pharmaceutical Chemistry
Email: Shdashyan@gmail.com
Armenia, pr. Azatutyan 26, Yerevan, 0014
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