Lewis acid-promoted direct synthesis of N-unsubstituted hydrazones via the reaction of hydrazine with acetophenone and isatin derivatives


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Hydrazones 2–22 were synthesized via the reaction of acetophenone with isatin derivatives and anhydrous hydrazine promoted by BF3 as a Lewis acid at 0°C. Structures of the synthesized hydrazones were determined on the basis of NMR and X-ray crystallographic analyses.

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A. El-Azab

Department of Pharmaceutical Chemistry, College of Pharmacy; Department of Organic Chemistry, Faculty of Pharmacy

编辑信件的主要联系方式.
Email: adelazaba@yahoo.com
沙特阿拉伯, Riyadh, 11451; Cairo

H. Ghabbour

Department of Pharmaceutical Chemistry, College of Pharmacy; Department of Medicinal Chemistry, Faculty of Pharmacy

Email: adelazaba@yahoo.com
沙特阿拉伯, Riyadh, 11451; Mansoura, 35516

W. El-Husseiny

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy

Email: adelazaba@yahoo.com
埃及, Mansoura, 35516

A. Maarouf

Department of Medicinal Chemistry, Faculty of Pharmacy; Department of Pharmaceutical Chemistry, College of Pharmacy

Email: adelazaba@yahoo.com
埃及, Mansoura, 35516; Gamasa City

M. Mohamed

Department of Organic Chemistry, Faculty of Pharmacy; Department of Pharmaceutical Chemistry, College of Pharmacy

Email: adelazaba@yahoo.com
埃及, Cairo; AlKharj

A. Abdel-Aziz

Department of Pharmaceutical Chemistry, College of Pharmacy; Department of Medicinal Chemistry, Faculty of Pharmacy

Email: adelazaba@yahoo.com
沙特阿拉伯, Riyadh, 11451; Mansoura, 35516

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