Modification of Polymyxin B1 by Water-Soluble Functional Copolymers of Vinyl Alcohol


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The condensation of the peptide antibiotic Polymyxin В1 with the vinyl alcohol copolymers containing aldehyde groups was studied. The structure and composition of the resulting conjugates were determined. The polymer derivatives of the antibiotic were shown to preserve their antimicrobial activity.

Sobre autores

V. Shalygina

Institute of Macromolecular Compounds

Autor responsável pela correspondência
Email: shalygina@hq.macro.ru
Rússia, Bol’shoi pr. V.O. 31, St. Petersburg, 199004

E. Vlasova

Institute of Macromolecular Compounds

Email: shalygina@hq.macro.ru
Rússia, Bol’shoi pr. V.O. 31, St. Petersburg, 199004

V. Gaydukova

St. Petersburg State Pharmaceutical Academy

Email: shalygina@hq.macro.ru
Rússia, St. Petersburg

E. Anan’eva

St. Petersburg State Pharmaceutical Academy

Email: shalygina@hq.macro.ru
Rússia, St. Petersburg

E. Panarin

Institute of Macromolecular Compounds; Petr Velikii State Polytechnical University

Email: shalygina@hq.macro.ru
Rússia, Bol’shoi pr. V.O. 31, St. Petersburg, 199004; St. Petersburg

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