Synthesis and characterization of novel pyran and pyranopyrimidines linked 8-hydroxy-7-iodoquinoline-5-sulfonamide derivatives

Resumo

Several novel 8-hydroxy-7-iodoquinoline-5-sulfonamides bearing pyran and pyrano[2,3-d]pyrimidine derivatives were synthesized via a one-pot base catalyzed cyclocondensation reaction of N-(4-acetylphenyl)-8-hydroxy-7-iodoquinoline-5-sulfonamide with malononitrile and arylaldehydes, followed by heterocyclization of the resulting intermediates with the appropriate reagents such as carbon disulphide, formic acid, thiourea, and formamide.