Synthesis of tetrahydroisoquinoline derivatives and evaluation of their anti-breast cancer activity

X. P. Zhang; F. J. Yu; X. W. Ding; X. M. He; D. H. Zou

doi:10.1134/S1070363216060311

Synthesis of tetrahydroisoquinoline derivatives and evaluation of their anti-breast cancer activity

Авторлар: Zhang X.P.¹, Yu F.J.², Ding X.W.¹, He X.M.¹, Zou D.H.¹
Мекемелер:
1. Department of Breast Tumor Surgery
2. Department of Medical Record Management
Шығарылым: Том 86, № 6 (2016)
Беттер: 1430-1433
Бөлім: Article
URL: https://bakhtiniada.ru/1070-3632/article/view/215464
DOI: https://doi.org/10.1134/S1070363216060311
ID: 215464

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Аннотация

Four novel tetrahydroisoquinoline derivatives 1–4 were synthesized and characterized by IR, ¹H NMR, HRMS, and single crystal X-ray crystallography. Anticancer effect of the products were studied on five human breast cancer cell lines including MDA-MB-231, MDA-MB-468, SK-BR-3, MCF7, HCC70 T4-2. Compounds 3 and 4 demonstrated higher activity than 1 and 2.